医学研究与教育
醫學研究與教育
의학연구여교육
MEDICAL RESEARCH AND EDUCATION
2014年
5期
89-91
,共3页
同型半胱氨酸%心血管疾病%H型疾病%预警
同型半胱氨痠%心血管疾病%H型疾病%預警
동형반광안산%심혈관질병%H형질병%예경
homocysteine%cardiovascular disease%H-type diseases%early warning
综述近年高同型半胱氨酸（Homocysteine, Hcy）血症的疾病预警及其研究的意义。查阅相关文献和总结了相关研究结果，在分析的基础上阐述了观点和建议。Hcy是人体一种非必需氨基酸，系甲硫氨酸的中间代谢产物；其血清中的参考值依性别、年龄不同有所差异，儿童4.8~15.0μmol/L，成人5~15μmol/L；高Hcy血症与心脑血管病、糖尿病肾病等慢性疾病的风险密切相关。对此，深入研究高Hcy血症与疾病危险相关性，阐明其发病机制，建立诊检“H型疾病”和防治该类疾病的预警措施，筛查和研制其治疗药物以及丰富临床治疗策略具有重要意义。
綜述近年高同型半胱氨痠（Homocysteine, Hcy）血癥的疾病預警及其研究的意義。查閱相關文獻和總結瞭相關研究結果，在分析的基礎上闡述瞭觀點和建議。Hcy是人體一種非必需氨基痠，繫甲硫氨痠的中間代謝產物；其血清中的參攷值依性彆、年齡不同有所差異，兒童4.8~15.0μmol/L，成人5~15μmol/L；高Hcy血癥與心腦血管病、糖尿病腎病等慢性疾病的風險密切相關。對此，深入研究高Hcy血癥與疾病危險相關性，闡明其髮病機製，建立診檢“H型疾病”和防治該類疾病的預警措施，篩查和研製其治療藥物以及豐富臨床治療策略具有重要意義。
종술근년고동형반광안산（Homocysteine, Hcy）혈증적질병예경급기연구적의의。사열상관문헌화총결료상관연구결과，재분석적기출상천술료관점화건의。Hcy시인체일충비필수안기산，계갑류안산적중간대사산물；기혈청중적삼고치의성별、년령불동유소차이，인동4.8~15.0μmol/L，성인5~15μmol/L；고Hcy혈증여심뇌혈관병、당뇨병신병등만성질병적풍험밀절상관。대차，심입연구고Hcy혈증여질병위험상관성，천명기발병궤제，건립진검“H형질병”화방치해류질병적예경조시，사사화연제기치료약물이급봉부림상치료책략구유중요의의。
To review the disease warning of hyperhomocysteinemia and its research signiifcance in recent years, the paper accessed to relevant documents, summarized the research results and demonstrated our suggestions based on the analysis. Homocysteine (Hcy) is a non-essential amino acids in the human body. The normal range of serum Hcy varies in accordance with age and gender. Hyperhomocysteinemia is closed related to cardiovascular and cerebrovascular disease, diabetic nephropathy and other chronic diseases. In this regard, it is signiifcant to clarify its pathogenesis, establish the diagnosis check of“H-type diseases”, screen and develop of drugs and accumulate clinical therapeutic strategies.
