医学研究与教育
醫學研究與教育
의학연구여교육
MEDICAL RESEARCH AND EDUCATION
2014年
5期
68-72
,共5页
高天初%李会敏%刘喜艳%史福平
高天初%李會敏%劉喜豔%史福平
고천초%리회민%류희염%사복평
卒中后抑郁%高同型半胱氨酸血症%临床研究
卒中後抑鬱%高同型半胱氨痠血癥%臨床研究
졸중후억욱%고동형반광안산혈증%림상연구
post-stroke depression(PSD)%hyperhomocysteinemia(HHcy)%clinical research
脑卒中患者的1/3发展为卒中后抑郁(post-stroke depression,PSD)。PSD加剧了脑卒中所带来的负面影响,增加了病死率,减缓了神经功能的恢复时间,削弱了恢复程度。目前研究表明高同型半胱氨酸血症(hyperhomocysteinemia, HHcy)与普通人群中的脑卒中的发生具有相关性,但其与PSD的发生尚未明确。近年来,有关二者之间各方面的相关性研究较多(如流行病学、病理生理学机制、临床表现、诊断评估及药物治疗等),引起了广泛关注。
腦卒中患者的1/3髮展為卒中後抑鬱(post-stroke depression,PSD)。PSD加劇瞭腦卒中所帶來的負麵影響,增加瞭病死率,減緩瞭神經功能的恢複時間,削弱瞭恢複程度。目前研究錶明高同型半胱氨痠血癥(hyperhomocysteinemia, HHcy)與普通人群中的腦卒中的髮生具有相關性,但其與PSD的髮生尚未明確。近年來,有關二者之間各方麵的相關性研究較多(如流行病學、病理生理學機製、臨床錶現、診斷評估及藥物治療等),引起瞭廣汎關註。
뇌졸중환자적1/3발전위졸중후억욱(post-stroke depression,PSD)。PSD가극료뇌졸중소대래적부면영향,증가료병사솔,감완료신경공능적회복시간,삭약료회복정도。목전연구표명고동형반광안산혈증(hyperhomocysteinemia, HHcy)여보통인군중적뇌졸중적발생구유상관성,단기여PSD적발생상미명학。근년래,유관이자지간각방면적상관성연구교다(여류행병학、병리생이학궤제、림상표현、진단평고급약물치료등),인기료엄범관주。
One third of all stroke survivors develop post-stroke depression(PSD). It’s negatively impacts stroke outcome with increased morbidity, mortality and poorer functional recovery. Accumulating data suggest that hyperhomocysteinemia(HHcy) be associated with the risk of stroke in the general population, but the relationship remains unclear in PSD patients. In recent years, there have been a lot of studies on the correlation between them in many aspects (such as epidemiology, pathophysiology, clinical manifestation, diagnosis, and biological treatment), which has aroused wide concern.