CAJ | 학술논문

随着再生医学研究的深入，干细胞移植已用于临床实验。目前成骨骼肌细胞、骨髓源性干细胞、间充质干细胞和心肌固有干细胞已应用于心肌再生治疗。其中C-kit阳性心肌干细胞移植，不仅对收缩性心力衰竭有明确疗效，而且从长远来看，无明显不良事件发生。现就与心肌再生相关细胞作一综述，阐述何类细胞更适于心脏疾患的治疗。
수착재생의학연구적심입，간세포이식이용우림상실험。목전성골격기세포、골수원성간세포、간충질간세포화심기고유간세포이응용우심기재생치료。기중C-kit양성심기간세포이식，불부대수축성심력쇠갈유명학료효，이차종장원래간，무명현불량사건발생。현취여심기재생상관세포작일종술，천술하류세포경괄우심장질환적치료。
Various researches on regenerative medicine were carried out experimentally, and selected modalities have been introduced to the clinical arena. So far skeletal myoblasts, bone marrow-derived cells, mesenchymal stromal cells, and resident cardiac cells have been applied for therapeutic myocardial regeneration. Among them, autologous transplantation of c-kit-positive cardiac stem cells in congestive heart failure patients resulted in an outstanding outcome, with long-lasting beneifcial effects without major adverse events. By reviewing these clinical trials, an endeavor was made to seek for an ideal cellular therapy for cardiovascular diseases.