CAJ | 학술논문

目的：研究幽门螺杆菌（HP）感染的1型糖尿病患者血浆胰岛细胞抗体（ICA）、谷氨酸脱羧酶抗体（GADA）及胰岛素抗体（IAA）阳性率并与HP阴性糖尿病进行比较，同时观察根除HP治疗前后的变化。方法应用ELISA法测定糖尿病抗体，应用奥美拉唑20 mg，2次/天；克拉霉素0.5 g，2次/天；阿莫西林1.0 g，2次/天三联方法根除HP，对治疗前后糖尿病抗体进行比较。结果 HP阳性的1型糖尿病患者ICA阳性率明显高于HP阴性1型糖尿病患者，并有统计学意义。2组间比较IAA及GADA阳性率差异无统计学意义。治疗前后比较IAA、ICA及GADA阳性率相似，差异无统计学意义（P>0.05）。结论HP感染使糖尿病患者ICA阳性率增加，根除HP治疗对GABA、IAA阳性率无影响。
목적：연구유문라간균（HP）감염적1형당뇨병환자혈장이도세포항체（ICA）、곡안산탈최매항체（GADA）급이도소항체（IAA）양성솔병여HP음성당뇨병진행비교，동시관찰근제HP치료전후적변화。방법응용ELISA법측정당뇨병항체，응용오미랍서20 mg，2차/천；극랍매소0.5 g，2차/천；아막서림1.0 g，2차/천삼련방법근제HP，대치료전후당뇨병항체진행비교。결과 HP양성적1형당뇨병환자ICA양성솔명현고우HP음성1형당뇨병환자，병유통계학의의。2조간비교IAA급GADA양성솔차이무통계학의의。치료전후비교IAA、ICA급GADA양성솔상사，차이무통계학의의（P>0.05）。결론HP감염사당뇨병환자ICA양성솔증가，근제HP치료대GABA、IAA양성솔무영향。
Objective To investigate the positive rates of islet cell autoantibody (ICA), glutamic acid decarboxylase antibody (GADA) and insulin autoantibody (IAA) in plasma of patients with type 1 diabetes mellitus (T1DM) and Helicobacter pylori (HP) infection versus patients with T1DM but not HP, and then to detect the changes in these antibodies after HP eradication. Methods HP was eradicated using triple therapy with omeprazole (20 mg, bid), clarithromycin (0.5 g, bid) and amoxicillin (1.0 g, bid). Before and after HP eradication, enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of diabetes-related antibodies. Results Compared with patients with T1DM, higher positive rate of ICA was observed in patients with both T1DM and HP infection. Furthermore, the result was statistically signiifcant. In contrast, there were no differences in GADA and IAA between two groups of patients. After HP eradication, the positive rates of ICA, GADA and IAA were not altered signiifcantly. conclusion HP infection elevates the positive rate of ICA in patients with T1DM, but HP eradication has no signiifcant effects on the levels of gADA and IAA.