现代仪器与医疗
現代儀器與醫療
현대의기여의료
Modern Instrument and Medical Treatment
2014年
6期
62-64
,共3页
黄阿三%林森%杨建云%肖炳坤%黄荣清
黃阿三%林森%楊建雲%肖炳坤%黃榮清
황아삼%림삼%양건운%초병곤%황영청
DHEA衍生物%高效液相色谱法%破坏试验%影响因素试验%稳定性
DHEA衍生物%高效液相色譜法%破壞試驗%影響因素試驗%穩定性
DHEA연생물%고효액상색보법%파배시험%영향인소시험%은정성
DHEA derivatives%HPLC%Destructive test Factors affecting the test%Stability
目的：通过破坏试验（强酸、强碱、氧化）考察建立高效液相色谱法的专属性；研究影响因素试验（高温、高湿、光照）中DHEA衍生物的外观性状、有关物质及含量的变化，初步考察其稳定性。方法：利用高效液相色谱法，通过与对照品比较，观察变化情况。结果：在高温和光照条件下，DHEA衍生物都比较稳定；在高湿条件下，虽然性状仍为白色粉末，但其含量会有所降低，只有99.4%。结论：DHEA衍生物在所有考察条件中均很稳定，但会引湿增重，故保存过程中应注意防潮。
目的：通過破壞試驗（彊痠、彊堿、氧化）攷察建立高效液相色譜法的專屬性；研究影響因素試驗（高溫、高濕、光照）中DHEA衍生物的外觀性狀、有關物質及含量的變化，初步攷察其穩定性。方法：利用高效液相色譜法，通過與對照品比較，觀察變化情況。結果：在高溫和光照條件下，DHEA衍生物都比較穩定；在高濕條件下，雖然性狀仍為白色粉末，但其含量會有所降低，隻有99.4%。結論：DHEA衍生物在所有攷察條件中均很穩定，但會引濕增重，故保存過程中應註意防潮。
목적：통과파배시험（강산、강감、양화）고찰건립고효액상색보법적전속성；연구영향인소시험（고온、고습、광조）중DHEA연생물적외관성상、유관물질급함량적변화，초보고찰기은정성。방법：이용고효액상색보법，통과여대조품비교，관찰변화정황。결과：재고온화광조조건하，DHEA연생물도비교은정；재고습조건하，수연성상잉위백색분말，단기함량회유소강저，지유99.4%。결론：DHEA연생물재소유고찰조건중균흔은정，단회인습증중，고보존과정중응주의방조。
Objective: Through destructive test (strong acid, strong alkali, oxidation) investigation to establish HPLC speciifcity; Study of factors affecting test (high temperature, high humidity, illumination) the appearance of DHEA derivatives, the change of the related substances and content, a preliminary investigation of its stability.Methods:Using high performance liquid chromatography (HPLC) method, through the comparison with the reference substance, the observed changes.Results:Under the condition of high temperature and illumination, DHEA derivatives are relatively stable; Under the condition of high humidity, although the character is still the white powder, but its content will be reduced, only 99.4%.Conclusion: DHEA derivatives in all conditions of inspection is stable, but will bring wet weight, so save the process should pay attention to moistureproof.
