CAJ | 학술논문

目的：探讨应用肾动态显像对肺癌术后大剂量顺铂（DDP）化疗方案患者的早期肾功能损害评价的临床价值。方法：61例肺癌术后首次应用大剂量顺铂为主化疗方案的患者，分别在术前和术后化疗1个周期结束时应用肾动态扫描测量肾小球滤过率（G F R）和实验室化验血清肾功尿素氮（B U N）、肌酐（C r）以及尿蛋白β2-微球蛋白（β2-M G）、α1-微球蛋白(α1-M G )指标。结果：61例患者化疗后GFR下降16%（t=8.46, P＜0.05）,肾功（BUN、Cr）、尿蛋白（β2-MG、α1-MG)变化不明显（P>0.05）。结论：肾动态显像监测G F R能够评价肺癌患者化疗后早期肾脏功能损害，具有早期诊断价值。
목적：탐토응용신동태현상대폐암술후대제량순박（DDP）화료방안환자적조기신공능손해평개적림상개치。방법：61례폐암술후수차응용대제량순박위주화료방안적환자，분별재술전화술후화료1개주기결속시응용신동태소묘측량신소구려과솔（G F R）화실험실화험혈청신공뇨소담（B U N）、기항（C r）이급뇨단백β2-미구단백（β2-M G）、α1-미구단백(α1-M G )지표。결과：61례환자화료후GFR하강16%（t=8.46, P＜0.05）,신공（BUN、Cr）、뇨단백（β2-MG、α1-MG)변화불명현（P>0.05）。결론：신동태현상감측G F R능구평개폐암환자화료후조기신장공능손해，구유조기진단개치。
Objective: To explore clinical value of evaluating the early effect of chemotherapy on renal function using renal dynamic imaging and laboratory tests of renal function and urinary protein in patients with lung cancer treated with high-dose cisplatin (DDP).Methods: Among 61 cases of lung cancer after the ifrst application of high-dose cisplatin chemotherapy, respectively in the preoperative and postoperative chemotherapy for 1 cycle, Glomerular ifltration rate(GFR), blood urea nitrogen(BUN), creatinine (Cr) ,and urinary β 2- microglobulin (β 2-MG), microglobulin (α1-MG), were tested using renal dynamic scanning. Results: GFR in 61 patients after chemotherapy was obviously decreased 23% in comparison with that before chemotherapy(t=8.46,P<0.05).However, it was not signiifcant change in renal function (BUN, Cr), urinary β 2- microglobulin (β 2-MG) and microglobulin (α 1-MG) (P>0.05).Conclusion: renal dynamic imaging is a valuable method in early diagnosis by measureing GFR to early functional damage valuation of patients with lung cancer after chemotherapy. It is worthy of popularization and application for clinicians.