CAJ | 학술논문

目的：探讨血清C反应蛋白（CRP）在老年脑梗死检测中的临床应用价值。方法回顾性分析我院神经内科2011年4月-2012年3月收治的65例（排除有多次发病患者）经临床确诊为脑梗死的老年患者临床资料，并作为观察组采用美国Beckman Unicel DXC800全自动生化分析仪免疫比浊法测定其血清CRP水平，同时应用同样方法随机采集前来体检的健康体检者60例作为对照组。观察对比2组血清 CRP水平变化。结果观察组 CRP平均浓度为（12．37±3．14）mg／L，明显高于对照组的（6．12±1．69）mg／L（P＜0．01）。神经功能缺损程度为轻度患者血清 hs-CRP浓度变化不大，但中度和重度患者则显著上升（P＜0．01）。大梗死病灶患者的血清 hs-CRP浓度明显高于中梗死病灶和小梗死病灶患者（P＜0．01），而后两者间对比则差异不明显（P＞0．05）。结论血清 CRP水平升高与脑梗死存在关联，CRP水平升高可作为缺血性脑梗死严重程度的危险因子。检测老年脑梗死患者血清 CRP水平对脑梗死早期诊断、判断病情程度和预后有着重要的临床参考价值。
목적：탐토혈청C반응단백（CRP）재노년뇌경사검측중적림상응용개치。방법회고성분석아원신경내과2011년4월-2012년3월수치적65례（배제유다차발병환자）경림상학진위뇌경사적노년환자림상자료，병작위관찰조채용미국Beckman Unicel DXC800전자동생화분석의면역비탁법측정기혈청CRP수평，동시응용동양방법수궤채집전래체검적건강체검자60례작위대조조。관찰대비2조혈청 CRP수평변화。결과관찰조 CRP평균농도위（12．37±3．14）mg／L，명현고우대조조적（6．12±1．69）mg／L（P＜0．01）。신경공능결손정도위경도환자혈청 hs-CRP농도변화불대，단중도화중도환자칙현저상승（P＜0．01）。대경사병조환자적혈청 hs-CRP농도명현고우중경사병조화소경사병조환자（P＜0．01），이후량자간대비칙차이불명현（P＞0．05）。결론혈청 CRP수평승고여뇌경사존재관련，CRP수평승고가작위결혈성뇌경사엄중정도적위험인자。검측노년뇌경사환자혈청 CRP수평대뇌경사조기진단、판단병정정도화예후유착중요적림상삼고개치。
Objective to investigate the serum level of C reactive protein(CRP)in elderly patients with cerebral in-farction in the clinical application value of detection.Methods a retrospective analysis of 65?cases in our hospital from 2011 April to 2012 March in Department of internal medicine were (exclude many patients diagnosed as clinical data)in elderly patients with cerebral infarction,and as the observation group were treated with American Beckman Unicel DXC800 automatic biochemical analyzerimmune serum CRP levels were measured by turbidimetry,and use the same method of random sampling come to medical examination of 60 cases of healthy people as control group.Changes of ser-um CRP levels in the 2 groups were observed and compared.Results in the observation group,the average concentra-tion of CRP was(12.37 ± 3.14)mg/L,significantly higher than that of the control group(6.12 ± 1.69)mg/L(P<0.01).The degree of neural function defect concentration changes of serum hs-CRP in patients with mild to moderate and severe patients is not big,butincreased significantly(P<0.01).The concentration of serum hs-CRP in patients withcerebral infarction was higher than that in the cerebral infarction and infarctionpatients(P<0.01),and then the difference between the two comparison is not obvious(P>0.05).Conclusion Elevated serum CRP levels are associated with cerebral infarction,elevated CRP levels may be a risk factor of ischemic stroke severity.The level of serum CRP detection in patients with cerebral infarction in the elderly has importantclinical value in the early diagnosis of cerebral infarction,j udging the severity of disease and prognosis.