CAJ | 학술논문

目的：探讨磁共振波谱成像（1 H-MRS）在肝硬化诊断与分期中的价值。方法选取30例不同程度的肝硬化患者（child A 15例，child B 8例，child C 7例）作为病例组和正常人30例作为对照组，对其行磁共振单体素1 H-MRS研究，测算病例组和对照组患者的相关代谢物（Lip，Glx，Cho，Glyu）平均峰值，并进行统计学分析。结果①与正常对照组相比，肝硬化患者的 Glx和 Cho峰值均高于对照组，Lip峰值低于对照组，且差异均有统计学意义（P＜0.05）；②不同程度肝硬化病例组内对比，Glyu、Cho 和 Glx的峰值均随着肝硬化程度升高而增大，Lip峰值随着肝硬化程度升高而减小，且 Lip 和Cho峰值的差异在 child A、child B和 child C组中均有统计学意义（P＜0．05），而 Glyu和Glx峰值差异均无统计学意义（P＞0．05）。结论磁共振波谱成像（1 H-MRS）作为一种无创性的评价手段，其所测代谢物峰值在一定程度上可以对肝硬化的诊断与分期做出较为准确的评估，为临床早期肝硬化的诊断及评估提供可靠的影像学依据。
목적：탐토자공진파보성상（1 H-MRS）재간경화진단여분기중적개치。방법선취30례불동정도적간경화환자（child A 15례，child B 8례，child C 7례）작위병례조화정상인30례작위대조조，대기행자공진단체소1 H-MRS연구，측산병례조화대조조환자적상관대사물（Lip，Glx，Cho，Glyu）평균봉치，병진행통계학분석。결과①여정상대조조상비，간경화환자적 Glx화 Cho봉치균고우대조조，Lip봉치저우대조조，차차이균유통계학의의（P＜0.05）；②불동정도간경화병례조내대비，Glyu、Cho 화 Glx적봉치균수착간경화정도승고이증대，Lip봉치수착간경화정도승고이감소，차 Lip 화Cho봉치적차이재 child A、child B화 child C조중균유통계학의의（P＜0．05），이 Glyu화Glx봉치차이균무통계학의의（P＞0．05）。결론자공진파보성상（1 H-MRS）작위일충무창성적평개수단，기소측대사물봉치재일정정도상가이대간경화적진단여분기주출교위준학적평고，위림상조기간경화적진단급평고제공가고적영상학의거。
Objective To evaluate the value of MR Spectroscopy (1 H-MRS)in diagnosis and stage of liver cirrho-sis.Methods Thirty patients with liver fibrosis(child A15 cases,child B 8 cases and child C 7 cases)and thirty normal patients were included.They were examined by GE Propeller HD 1.5T MRI system in Prob-P.The metabolism value (Lip,Glx,Cho,Glyu)in liver are calculated and statistically analyzed.Results ①The value of choline and glutamine/glutamate in liver cirrhosis are higher but the value of lipid is lower.A significant statistical difference was observed be-tween control vs.liver cirrhosis in choline and glutamine/glutamate and lipid (P<0.05),whereas no significant statisti-cal difference was observed in glycogen.②Among different child groups,the value of choline,glutamine/glutamate and glycogen increase as the degree of liver cirrhosis,but the value of lipid decrease as the degree of liver cirrhosis.A signif-icantly statistical difference was observed between A vs.B,B vs.C and A vs.C in choline and lipid (P<0.05),howev-er,no significant statistical difference was observed in glycogen and glutamine/glutamate.Conclusion MRS can be used in diagnosis and stage of liver cirrhosis as a noninvasive means,and provide reliable imaging basis in clinical diagnosis of liver cirrhosis.