中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2014年
11期
1800-1802
,共3页
慢性鼻-鼻窦炎%变应原%特异性 IgE%变态反应%免疫学
慢性鼻-鼻竇炎%變應原%特異性 IgE%變態反應%免疫學
만성비-비두염%변응원%특이성 IgE%변태반응%면역학
chronic rhinosinusitis%allergen%specific IgE%allergic reaction%immunology
目的：观察和分析慢性鼻-鼻窦炎（CRS）患者血清特异性 IgE（sIgE）检测的临床意义。方法选取120例CRS患者作为研究对象，对所有纳入患者的血清 sIgE和总 IgE（tIgE）进行半定量检测，根据 sIgE检测结果将纳入患者分为 sIgE阳性组和 sIgE阴性组，根据 tIgE检测结果将纳入患者分为 tIgE阳性组和 tIgE阴性组。对各组患者的伴发鼻息肉情况、合并哮喘情况、鼻内镜 Lund评分、鼻窦 Lund-Mackay CT评分进行观察和比较。结果纳入患者中的 tIgE阳性例数为62例，阳性率为51．67％，sIgE阳性例数为18例，阳性率为15％；tIgE阳性组患者与 tIgE阴性组患者的各项临床表现的差异均无显著性（P＞0．05），sIgE阳性组患者的合并哮喘比例和内镜评分均显著高于 sIgE阴性组（P＜0．05），两组患者的伴息肉情况和CT评分的差异无显著性（P＞0．05）。结论 CRS患者的变应反应程度较高，致敏变应原以室内吸入性变应原为主，多为混合性致敏，血清 sIgE检测有助于明确诱发 CRS的变应原种类，并可用于辅助预测患者的鼻粘膜病变程度和预后情况。
目的：觀察和分析慢性鼻-鼻竇炎（CRS）患者血清特異性 IgE（sIgE）檢測的臨床意義。方法選取120例CRS患者作為研究對象，對所有納入患者的血清 sIgE和總 IgE（tIgE）進行半定量檢測，根據 sIgE檢測結果將納入患者分為 sIgE暘性組和 sIgE陰性組，根據 tIgE檢測結果將納入患者分為 tIgE暘性組和 tIgE陰性組。對各組患者的伴髮鼻息肉情況、閤併哮喘情況、鼻內鏡 Lund評分、鼻竇 Lund-Mackay CT評分進行觀察和比較。結果納入患者中的 tIgE暘性例數為62例，暘性率為51．67％，sIgE暘性例數為18例，暘性率為15％；tIgE暘性組患者與 tIgE陰性組患者的各項臨床錶現的差異均無顯著性（P＞0．05），sIgE暘性組患者的閤併哮喘比例和內鏡評分均顯著高于 sIgE陰性組（P＜0．05），兩組患者的伴息肉情況和CT評分的差異無顯著性（P＞0．05）。結論 CRS患者的變應反應程度較高，緻敏變應原以室內吸入性變應原為主，多為混閤性緻敏，血清 sIgE檢測有助于明確誘髮 CRS的變應原種類，併可用于輔助預測患者的鼻粘膜病變程度和預後情況。
목적：관찰화분석만성비-비두염（CRS）환자혈청특이성 IgE（sIgE）검측적림상의의。방법선취120례CRS환자작위연구대상，대소유납입환자적혈청 sIgE화총 IgE（tIgE）진행반정량검측，근거 sIgE검측결과장납입환자분위 sIgE양성조화 sIgE음성조，근거 tIgE검측결과장납입환자분위 tIgE양성조화 tIgE음성조。대각조환자적반발비식육정황、합병효천정황、비내경 Lund평분、비두 Lund-Mackay CT평분진행관찰화비교。결과납입환자중적 tIgE양성례수위62례，양성솔위51．67％，sIgE양성례수위18례，양성솔위15％；tIgE양성조환자여 tIgE음성조환자적각항림상표현적차이균무현저성（P＞0．05），sIgE양성조환자적합병효천비례화내경평분균현저고우 sIgE음성조（P＜0．05），량조환자적반식육정황화CT평분적차이무현저성（P＞0．05）。결론 CRS환자적변응반응정도교고，치민변응원이실내흡입성변응원위주，다위혼합성치민，혈청 sIgE검측유조우명학유발 CRS적변응원충류，병가용우보조예측환자적비점막병변정도화예후정황。
Objective To observe and analyze the clinical meaning of the serum specific IgE (s IgE)detection of the patients with chronic rhinosinusitis (CRS).Methods 120 cases of CRS patients were selected as the research objects. The serum sIgE and total IgE (tIgE)levels of the included patients were detected by semi quantitative detection.The patients were divided into the sIgE positive group and the sIgE negative group according to the results of sIgE detec-tion,and divided into the tIgE positive group and the tIgE negative group according to the results of tIgE detection.The incidences of complicated nasal polyps,complicated asthma,nasal endoscopic sinus Lund score,nasal sinus Lund-Mac-kay CT score of the patients in each groups were observed and compared.Results 62 cases of the patients were with the positive results of tIgE detection and the positive rate was 51.67%.18 cases of the patients were with the positive results of sIgE detection and the positive rate was 1 5%;there were no significant differences of the clinical manifesta-tions between the tIgE positive group and the tIgE negative group (P>0.05).the proportion of the patients complicat-ed with asthma and the nasal endoscopic scores of the patients in the sIgE positive group were significantly higher than those of the sIgE negative group (P<0.05).The differences of the proportion of the patients complicated with nasal polyps and CT scores between the patients in the two groups were not significant (P>0.05).Conclusion The degree of allergic reaction of the CRS patients is relatively high,most of the allergen is indoor inhalant allergen,and the sensiti-zation is mostly mixed.The detection of serum sIgE is helpful to clear the category of the allergen and can be used to aid the prediction of the severity of the nasal mucosa damages and the prognosis prediction of the patients with CRS.
