CAJ | 학술논문

目的：探讨2型糖尿病患者皮肤晚期糖基化终末产物（AGEs）与血清 AGEs的相关性，评估皮肤 AGEs检测的可靠性。方法2型糖尿病患者74例（糖尿病组），分别使用皮肤荧光光谱法检测皮肤 AGEs 和 ELISA法测定血清 AGEs，正常对照组33例，为同期体检健康人群。结果糖尿病组皮肤 AGEs和血清 AGEs水平明显高于正常对照组，差异有统计学意义，P＜0．01；皮肤 AGEs与血清 AGEs呈显著正相关（r＝0．939，P＜0．01）。结论皮肤荧光光谱法测定皮肤 AGEs可反映人体体内 AGEs水平。
목적：탐토2형당뇨병환자피부만기당기화종말산물（AGEs）여혈청 AGEs적상관성，평고피부 AGEs검측적가고성。방법2형당뇨병환자74례（당뇨병조），분별사용피부형광광보법검측피부 AGEs 화 ELISA법측정혈청 AGEs，정상대조조33례，위동기체검건강인군。결과당뇨병조피부 AGEs화혈청 AGEs수평명현고우정상대조조，차이유통계학의의，P＜0．01；피부 AGEs여혈청 AGEs정현저정상관（r＝0．939，P＜0．01）。결론피부형광광보법측정피부 AGEs가반영인체체내 AGEs수평。
Objective To explore the correlation between skin advanced glycation end products(SAGEs)and serum AGEs in type 2 diabetes and evaluate the reliability of SAGEs detection.Methods 74 patients with type 2 diabetes were recruited,SAGEs were measured by using skin autofluorescence spectrometry method,serum AGEs were meas-ured by using ELISA method,33 healthy people were selected as normal control group.Results Compared with control group,the SAGEs level were obviously increased in patients with type 2 diabetes,P<0.01,and the level of serum AGEs were also increased in diabetes,P<0.01,the SAGEs and serum AGEs were significant positive correlation(r=0.939,P<0.01).Conclusion SAGEs measured by skin autofluorescence spectrometry method could be used to reflect the AGEs level in vivo.