CAJ | 학술논문

目的：探讨急性加重期慢性阻塞性肺疾病（ COPD）患者血清C反应蛋白（ CRP）及降钙素原（ PCT）的变化及临床意义。方法纳入急性加重期COPD患者120例，同时按随机数字表法抽取COPD稳定期患者120例，所有受试者均给予相应的对症支持治疗，观察治疗前、治疗后1 d、7 d、14 d患者血清CRP与PCT水平变化。结果与治疗前相比，治疗后1 d、7 d、14 d急性加重期COPD患者血清 CRP[（12．32±6．59）mg／L、（9．05±3．31）mg／L、（7．31±2．31）mg／L、（4．45±1．54）mg／L]与PCT[（0．34±0．05）μg／L、（0．26±0．04）μg／L、（0．18±0．04）μg／L、（0．10±0．03）μg／L]水平呈下降趋势，不同时间点差异有统计学意义（均P＜0．05）；与稳定期患者相比，治疗前、治疗后1 d、7 d血清CRP与PCT水平均明显高，差异有统计学意义（均P＜0．05）；但治疗后14 d血清CRP与PCT水平差异无统计学意义（P＞0．05）。结论急性加重期COPD患者早期血清CRP及PCT水平明显增高，治疗后其水平明显下降，联合观察血清CRP及PCT水平可以更好地反映COPD急性加重期的炎性反应。
목적：탐토급성가중기만성조새성폐질병（ COPD）환자혈청C반응단백（ CRP）급강개소원（ PCT）적변화급림상의의。방법납입급성가중기COPD환자120례，동시안수궤수자표법추취COPD은정기환자120례，소유수시자균급여상응적대증지지치료，관찰치료전、치료후1 d、7 d、14 d환자혈청CRP여PCT수평변화。결과여치료전상비，치료후1 d、7 d、14 d급성가중기COPD환자혈청 CRP[（12．32±6．59）mg／L、（9．05±3．31）mg／L、（7．31±2．31）mg／L、（4．45±1．54）mg／L]여PCT[（0．34±0．05）μg／L、（0．26±0．04）μg／L、（0．18±0．04）μg／L、（0．10±0．03）μg／L]수평정하강추세，불동시간점차이유통계학의의（균P＜0．05）；여은정기환자상비，치료전、치료후1 d、7 d혈청CRP여PCT수평균명현고，차이유통계학의의（균P＜0．05）；단치료후14 d혈청CRP여PCT수평차이무통계학의의（P＞0．05）。결론급성가중기COPD환자조기혈청CRP급PCT수평명현증고，치료후기수평명현하강，연합관찰혈청CRP급PCT수평가이경호지반영COPD급성가중기적염성반응。
Objective To explore clinical significance of C-reactive protein( CRP) and procalcitonin ( PCT) in chronic obstructive pulmonary disease( COPD) with acute exacerbation.Methods Included 120 COPD patients with acute exacerbations,and at the same time,according to the random number table method,120 COPD patients with stable were extracted, all respondents were given corresponding symptomatic support treatment, observation before treatment,after treatment,the 1d,7d,14d patients serum levels of CRP was associated with change PCT level. Results Compared with before treatment, after treatment, the serum levels of CRP of COPD patients with acute exacerbation of at 1d,7d,14d was associated with a decline in PCT level, different time points more statistically significant difference( all P<0.05);Compared with patients with stable,before treatment,after treatment,the 1d,7d serum levels of CRP[(12.32 ±6.59)mg/L,(9.05 ±3.31)mg/L,(7.31 ±2.31)mg/L,(4.45 ±1.54)mg/L]was associated with a high level of PCT[(0.34 ±0.05)μg/L,(0.26 ±0.04)μg/L,(0.18 ±0.04)μg/L,(0.10 ± 0.03)μg/L]were obvious,more statistically significant difference(all P<0.05);But after treatment,serum CRP was associated with differences in the level was no statistical comparison PCT significance ( P >0.05 ) .Conclusion COPD patients with acute exacerbation of serum CRP and early PCT significantly higher level,its level after treatment dropped significantly,joint observation CRP and serum PCT level can reflect COPD acute exacerbation issue of the inflammatory reaction.