中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
23期
3558-3560
,共3页
降钙素原%脓毒血症%预后%相关性
降鈣素原%膿毒血癥%預後%相關性
강개소원%농독혈증%예후%상관성
Procalcitonin%Septicemia%Prognosis%Relevance
目的：探讨血清降钙素原（ PCT）水平检测在脓毒血症预后判断中的临床价值。方法选取113例感染患者为研究对象，根据是否伴有脓毒血症分为观察组（脓毒血症）和对照组（非脓毒血症）。于患者入院时抗生素治疗前抽取患者静脉血2 mL应用免疫发光法检测PCT水平。比较两组入院时及入院后PCT水平，分析其与患者病情变化及预后的关系。结果观察组PCT（11．03±6．21）ng／mL，显著高于对照组的[（0．81±1．61）ng／mL]（t＝8．507，P＜0．01）；脓毒血症死亡患者血清PCT水平随着时间推移明显上升（F＝5．061，P＜0．05）；无效患者血清PCT水平随病情加重而显著升高（F＝4．793，P＜0．05）；好转患者血清PCT水平随病情好转而降低（F＝6．009，P＜0．05）。且PCT＜10 ng／mL者病死率（14．89％）明显低于PCT≥10 ng／mL患者（72．22％）。结论 PCT对预测脓毒血症的预后具有重要的临床价值，值得临床推广和应用。
目的：探討血清降鈣素原（ PCT）水平檢測在膿毒血癥預後判斷中的臨床價值。方法選取113例感染患者為研究對象，根據是否伴有膿毒血癥分為觀察組（膿毒血癥）和對照組（非膿毒血癥）。于患者入院時抗生素治療前抽取患者靜脈血2 mL應用免疫髮光法檢測PCT水平。比較兩組入院時及入院後PCT水平，分析其與患者病情變化及預後的關繫。結果觀察組PCT（11．03±6．21）ng／mL，顯著高于對照組的[（0．81±1．61）ng／mL]（t＝8．507，P＜0．01）；膿毒血癥死亡患者血清PCT水平隨著時間推移明顯上升（F＝5．061，P＜0．05）；無效患者血清PCT水平隨病情加重而顯著升高（F＝4．793，P＜0．05）；好轉患者血清PCT水平隨病情好轉而降低（F＝6．009，P＜0．05）。且PCT＜10 ng／mL者病死率（14．89％）明顯低于PCT≥10 ng／mL患者（72．22％）。結論 PCT對預測膿毒血癥的預後具有重要的臨床價值，值得臨床推廣和應用。
목적：탐토혈청강개소원（ PCT）수평검측재농독혈증예후판단중적림상개치。방법선취113례감염환자위연구대상，근거시부반유농독혈증분위관찰조（농독혈증）화대조조（비농독혈증）。우환자입원시항생소치료전추취환자정맥혈2 mL응용면역발광법검측PCT수평。비교량조입원시급입원후PCT수평，분석기여환자병정변화급예후적관계。결과관찰조PCT（11．03±6．21）ng／mL，현저고우대조조적[（0．81±1．61）ng／mL]（t＝8．507，P＜0．01）；농독혈증사망환자혈청PCT수평수착시간추이명현상승（F＝5．061，P＜0．05）；무효환자혈청PCT수평수병정가중이현저승고（F＝4．793，P＜0．05）；호전환자혈청PCT수평수병정호전이강저（F＝6．009，P＜0．05）。차PCT＜10 ng／mL자병사솔（14．89％）명현저우PCT≥10 ng／mL환자（72．22％）。결론 PCT대예측농독혈증적예후구유중요적림상개치，치득림상추엄화응용。
Objective To explore the correlation of serum procalcitonin and prognosis of neonatal sepsis. Methods 113 cases of infection were selected as the objects of study,which were divided into the observation group ( sepsis) and control group ( non sepsis) according to the presence of sepsis.2mL venous blood was selected when patients were admitted to hospital before antibiotic treatment.The level of PCT was detected by immunoluminometric assay.PCT level at admission and after treatment were used to analyze the relationship between changes and the severity and prognosis of patients.Results PCT level of the observation group [(11.03 ±6.21)ng/mL] were higher than that of the control group [(0.81 ±1.61)ng/mL] (t=8.507,P<0.01),Sepsis and death in patients with serum PCT values increased significantly over time (F=5.061,P<0.05);invalid value of serum PCT in patients with disease exacerbation was significantly higher(F=4.793,P<0.05);improved serum PCT values in patients with the disease better reduced(F=6.009,P<0.05).While PCT<14.86ng/mL mortality rate (14.89%) was significantly lower than the PCT≥14.86ng/mL mortality rate (72.22%).Conclusion PCT shows important clinical efficacy in forcasting prognosis of neonatal sepsis.It is worthy of wider promotion and application.
