CAJ | 학술논문

目的：研究巨噬细胞炎症蛋白-1α（ MIP-1α）、骨硬化蛋白与多发性骨髓瘤（ MM）并发骨髓瘤骨病（ MBD）的关系。方法以52例MM患者为观察组，其中无骨病者9例，有骨病者43例；MBD分级：0级9例、1级8例、2级21例、3级14例；选取28例健康体检者为对照组。分析MIP-1α、骨硬化蛋白与MBD的关系。结果观察组MIP-1α及骨硬化蛋白分别为（158．43±78．75）pg／mL、（0．62±0．24）pg／mL，均明显高于对照组的（52．46±21．35）pg／mL、（0．31±0．14）pg／mL（t＝9．635，P＜0．05；t＝8．844，P＜0．05）；MIP-1α、骨硬化蛋白随临床分期增加而逐渐升高（P＜0．05）；有骨病组MIP-1α及骨硬化蛋白分别为（175．55±62．75）pg／mL、（0.84±0．54）pg／mL，明显高于无骨病组的（89．83±41．57）pg／mL、（0．42±0．25）pg／mL（t＝7．665，P＜0．05；t＝6．834，P＜0．05）；MIP-1α和骨硬化蛋白与骨病分级存在相关性（r＝0．572，P＜0．05；r＝0．683，P＜0．05）。MIP-1α与骨硬化蛋白呈正相关（r＝0．522，P＜0．05）。结论 MM患者MIP-1α及骨硬化蛋白水平明显升高，两者均与MBD呈正相关，且两者之间也具有明显相关性，联合检测可作为评估MBD的重要指标。
목적：연구거서세포염증단백-1α（ MIP-1α）、골경화단백여다발성골수류（ MM）병발골수류골병（ MBD）적관계。방법이52례MM환자위관찰조，기중무골병자9례，유골병자43례；MBD분급：0급9례、1급8례、2급21례、3급14례；선취28례건강체검자위대조조。분석MIP-1α、골경화단백여MBD적관계。결과관찰조MIP-1α급골경화단백분별위（158．43±78．75）pg／mL、（0．62±0．24）pg／mL，균명현고우대조조적（52．46±21．35）pg／mL、（0．31±0．14）pg／mL（t＝9．635，P＜0．05；t＝8．844，P＜0．05）；MIP-1α、골경화단백수림상분기증가이축점승고（P＜0．05）；유골병조MIP-1α급골경화단백분별위（175．55±62．75）pg／mL、（0.84±0．54）pg／mL，명현고우무골병조적（89．83±41．57）pg／mL、（0．42±0．25）pg／mL（t＝7．665，P＜0．05；t＝6．834，P＜0．05）；MIP-1α화골경화단백여골병분급존재상관성（r＝0．572，P＜0．05；r＝0．683，P＜0．05）。MIP-1α여골경화단백정정상관（r＝0．522，P＜0．05）。결론 MM환자MIP-1α급골경화단백수평명현승고，량자균여MBD정정상관，차량자지간야구유명현상관성，연합검측가작위평고MBD적중요지표。
Objective To investigate the relationship between macrophage inflammatory protein 1-α( MIP-1α) ,sclerostin and multiple myeloma bone disease( MBD) .Methods 52 patients with multiple myeloma were selected as the observation group,among them,9 cases without MBD,43 cases with MBD;MBD grade:9 cases with grade 0,8 cases with grade 1,21 cases with grade 2,14 cases with grade 3.25 healthy examinee were selected as the control group.MIP-1αand sclerostin were observed.Results MIP-1α,sclerostin in the observation group[(158.43 ± 78.75)pg/mL,(0.62 ±0.24)pg/mL] were higher than those in the control group[(52.46 ±21.35)pg/mL,(0.31 ± 0.14)pg/mL](t =9.635,P <0.05;t =8.844,P <0.05);MIP-1α,sclerostin of MBD patients[(175.55 ± 62.75)pg/mL,(0.84 ±0.54)pg/mL]were higher than those of non MBD patients[(89.83 ±41.57)pg/mL,(0.42 ± 0.25)pg/mL](t=7.665,P<0.05;t=6.834,P<0.05).There were positive relation between MIP-1α,sclerostin and the grade of MBD(r=0.572,P<0.05;r=0.683,P<0.05).There was positive relation between the expressions of MIP-1αand sclerostin(r =0.522,P <0.05).Conclusion MIP-1αand sclerostin of patients with MM have increased.There is a significant relation between MIP-1α, sclerostin and MBD.United detection of MIP-1αand sclerostin may be an index used as evaluation of MBD.