CAJ | 학술논문

凋亡是细胞的一种基本生物学现象,在机体生命过程中发挥着重要作用。 miRNAs是在真核生物内发现的一类长度约22个核苷酸的内源性非编码单链小RNA,通过调控靶基因的表达参与调控细胞的凋亡、分化、增殖、侵袭和代谢。大量的研究表明, miR-21作为miRNAs重要成员之一,与细胞凋亡有重要联系。本文将从miR-21的生成、表达调控及对细胞凋亡的影响方面进行综述。
조망시세포적일충기본생물학현상,재궤체생명과정중발휘착중요작용。 miRNAs시재진핵생물내발현적일류장도약22개핵감산적내원성비편마단련소RNA,통과조공파기인적표체삼여조공세포적조망、분화、증식、침습화대사。대량적연구표명, miR-21작위miRNAs중요성원지일,여세포조망유중요련계。본문장종miR-21적생성、표체조공급대세포조망적영향방면진행종술。
Apoptosis is a basic biological phenomenon, which plays a key role in physiological and pathologi-cal process. miRNAs are a small class of endogenous non-coding, single-stranded RNA of about 22 nucleotides in length, which are found in eukaryotes, and can regulate cell apoptosis, differentiation, proliferation, inva-sion and metabolism via regulating expression of target gene. Particularly, as one of miRNAs, miR-21 and its function in regulating cell apoptosis has been reported in extensive studies. This paper reviewed the biogenesis and expression regulations of miR-21and its role in regulating apoptosis.