CAJ | 학술논문

动物肠道益生菌具有免疫调节、形成肠黏膜上皮屏障功能和刺激肠道细胞增殖等多种生理作用。最新研究表明,益生菌一个重要作用机制是可通过调控肠道自由基的水平,既可发挥免疫调节作用,又避免了对肠道产生氧化损伤。益生菌能够刺激肠道细胞产生活性氧自由基( ROS),ROS参与调控肠道细胞内的氧化还原反应过程。同时,益生菌也能够利用其体内相关的酶系,清除肠道细胞产生的过量ROS,从而防止其对肠道的损伤作用。本文对益生菌通过调控肠道自由基水平,既可发挥免疫调节作用,又防止对肠道氧化损伤的功能及其相关机制进行了综述。
동물장도익생균구유면역조절、형성장점막상피병장공능화자격장도세포증식등다충생리작용。최신연구표명,익생균일개중요작용궤제시가통과조공장도자유기적수평,기가발휘면역조절작용,우피면료대장도산생양화손상。익생균능구자격장도세포산생활성양자유기( ROS),ROS삼여조공장도세포내적양화환원반응과정。동시,익생균야능구이용기체내상관적매계,청제장도세포산생적과량ROS,종이방지기대장도적손상작용。본문대익생균통과조공장도자유기수평,기가발휘면역조절작용,우방지대장도양화손상적공능급기상관궤제진행료종술。
Probiotics play many physiological functions, such as immune regulation, epithelial barrier forma-tion and cell proliferation in the intestines. The recent researches showed that probiotics could regulate the level of reactive oxygen species ( ROS) in the gut, which may be the important mechanism of probiotics to play the physiological functions. Probiotics can stimulate the release of ROS in the intestines, as signaling secondary messengers to regulate the intestinal redox process. Meanwhile probiotics can eliminate the excessive ROS re-leased by intestinal cells to prevent the intestinal damage caused by ROS. This paper reviewed how probiotics regulate the level of ROS in the gut, and perform both immunity and antioxidant functions.