广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2014年
22期
105-107,161
,共4页
单分散聚甲基丙烯酸环氧丙酯树脂%去甲万古霉素手性固定相%高效液相色谱%手性分离
單分散聚甲基丙烯痠環氧丙酯樹脂%去甲萬古黴素手性固定相%高效液相色譜%手性分離
단분산취갑기병희산배양병지수지%거갑만고매소수성고정상%고효액상색보%수성분리
monodisperse poly (glycidylmethacrylate-co-ethylenedimethacrylate) beads%NVC-CSP%high performance liquid chromatography%chiral separation
以去甲万古霉素为手性选择剂,采用4,4-二苯基甲烷异氰酸酯作为间隔臂,将其键合到氨化的单分散交联聚甲基丙烯酸环氧丙酯微球上,合成了去甲万古霉素手性固定相。该键合固定相在极性有机相模式下,成功地实现了五种手性药物对映体的分离,详细考察了流动相组成、酸碱添加剂用量、温度和流速等对药物对映异构的拆分影响,并初步探讨了其手性识别机理。
以去甲萬古黴素為手性選擇劑,採用4,4-二苯基甲烷異氰痠酯作為間隔臂,將其鍵閤到氨化的單分散交聯聚甲基丙烯痠環氧丙酯微毬上,閤成瞭去甲萬古黴素手性固定相。該鍵閤固定相在極性有機相模式下,成功地實現瞭五種手性藥物對映體的分離,詳細攷察瞭流動相組成、痠堿添加劑用量、溫度和流速等對藥物對映異構的拆分影響,併初步探討瞭其手性識彆機理。
이거갑만고매소위수성선택제,채용4,4-이분기갑완이청산지작위간격비,장기건합도안화적단분산교련취갑기병희산배양병지미구상,합성료거갑만고매소수성고정상。해건합고정상재겁성유궤상모식하,성공지실현료오충수성약물대영체적분리,상세고찰료류동상조성、산감첨가제용량、온도화류속등대약물대영이구적탁분영향,병초보탐토료기수성식별궤리。
An antibiotic named norvancomycin was used as a new chiral selector, with 4,4-two phenyl methane diisocyanate as spacer arm to synthesis on the monodisperse poly ( glycidylmethacrylate-co-ethylenedimethacrylate ) beads for the preparation of norvancomycin-bonded chiral stationary phase ( NVC-CSP ) . The possible mechanisms of chiral discrimination were also discussed based on the enantioseparation of versatile structures of chiral compounds under different chromatographic modes. The mechanism of chiral separation was preliminarily studied.