CAJ | 학술논문

目的：比较甲地孕酮联合NP方案和单用NP方案化疗对晚期非小细胞肺癌生活质量的影响，评价甲地孕酮的临床疗效。方法：将60例晚期非小细胞肺癌患者随机分为治疗组与对照组。治疗组30例，于化疗前2天口服甲地孕酮160 mg，2次/d，同时予NP方案化疗。对照组30例仅接受NP方案化疗。于化疗4周期后评价患者的食欲、体重变化、KPS评分及不良反应。结果：经过4个周期后治疗组食欲、体重、KPS评分改善情况与对照组相比差异有统计学意义（P＜0.05）。治疗组主要不良反应为高血压、便秘、血糖升高、皮疹、阴道流血、踝部水肿等反应，经对症处理后可缓解。结论：甲地孕酮可改善晚期非小细胞肺癌患者的生活质量，减轻其不良反应，不良反应可耐受。
목적：비교갑지잉동연합NP방안화단용NP방안화료대만기비소세포폐암생활질량적영향，평개갑지잉동적림상료효。방법：장60례만기비소세포폐암환자수궤분위치료조여대조조。치료조30례，우화료전2천구복갑지잉동160 mg，2차/d，동시여NP방안화료。대조조30례부접수NP방안화료。우화료4주기후평개환자적식욕、체중변화、KPS평분급불량반응。결과：경과4개주기후치료조식욕、체중、KPS평분개선정황여대조조상비차이유통계학의의（P＜0.05）。치료조주요불량반응위고혈압、편비、혈당승고、피진、음도류혈、과부수종등반응，경대증처리후가완해。결론：갑지잉동가개선만기비소세포폐암환자적생활질량，감경기불량반응，불량반응가내수。
Objective To evaluate the quality of life in patients with non-small cell lung cancer in treatment with megestrol acetate combine with chemical therapy or the latter only,in order to estimate the efficacy of megestrol.Methods Sixty patients with non-small cell lung cancer were randomly assigned to treatment group and control group.The treated group of 30 patients was orally given megestrol(160 mg bid) two days before chemical therapy.The control group of 30 patients received chemical therapy only.After 4 cycles therapy,we evaluated the appetite、weight、KPS score and adverse reactions of the two groups respectively.Results Four cycles after treatment,The appetite、weight gain and KPS score were statistically significant compared with the control group(P<0.05).The major adverse reaction of the treatment group were hypertension,constip ation,vaginal bleeding,rash,high blood glucose,ankle edema.Through thrapy,the adverse reactions can be controlled.Conclusion Megestrol can improve the quality of life in patients with non-small cell lung cancer,relier the toxicity of them,and the adverse effects were tolerable.