CAJ | 학술논문

KA2012HRS复合提取液是以新鲜海参为主料的口服生物制剂，具有良好的抗疲劳、提高免疫力的功效。研究发现KA2012HRS复合提取液具有良好的体外抗肿瘤活性，同时可有效克服 P‐gp介导的肿瘤多药耐药，并且具有一定的肿瘤细胞选择性。对KA2012HRS复合提取液抗肿瘤机理进行了初步研究，结果表明：KA2012HRS复合提取液与K562／S细胞相互作用后，可将其细胞周期阻滞在S期，并使其线粒体膜电位显著降低，从而诱导该细胞发生凋亡。本研究提示，KA2012HRS复合提取液将具有良好的开发前景。
KA2012HRS복합제취액시이신선해삼위주료적구복생물제제，구유량호적항피로、제고면역력적공효。연구발현KA2012HRS복합제취액구유량호적체외항종류활성，동시가유효극복 P‐gp개도적종류다약내약，병차구유일정적종류세포선택성。대KA2012HRS복합제취액항종류궤리진행료초보연구，결과표명：KA2012HRS복합제취액여K562／S세포상호작용후，가장기세포주기조체재S기，병사기선립체막전위현저강저，종이유도해세포발생조망。본연구제시，KA2012HRS복합제취액장구유량호적개발전경。
KA2012HRS is a complex oral solution ,which is made mainly from fresh sea cucumber .It exhibits excellent fatigue resistance and immune system improving function .Our study indicates that KA2012HRS shows excellent in vitro tumor‐specific cytotoxicity and the ability to overcome P‐gp‐mediated multidrug‐resistance .The study on the mechanism of tumor cell killing by KA 2012HRS in‐dicates that KA2012HRS could arrest the cell cycle of K562/S in the S phase and it also could cause the loss of mitochondrial membrane potential(MMP)of K562/S cells ,through which KA2012HRS in‐duce the apoptosis of K562/S .Therefore ,KA2012HRS shows promising potency for further develop‐ment .