CAJ | 학술논문

目的：探讨炎琥宁注射剂致不良反应的一般规律和特点，寻找相关风险因素，为临床安全、合理用药提供参照。方法以“炎琥宁”，“不良反应”为检索词，检索中国期刊全文数据库，按纳入与排除标准共纳入53篇文献，进行资料的提取与统计分析。结果儿童患者发生率高，累及系统-器官主要为皮肤及其附件损害、全身性损害、呼吸系统损害等，不良反应以皮疹、发热、过敏反应等最为常见，严重可致过敏性休克。结论重视炎琥宁注射剂引起的不良反应，加强儿童用药监测，防范不良反应发生，确保临床用药安全。
목적：탐토염호저주사제치불량반응적일반규률화특점，심조상관풍험인소，위림상안전、합리용약제공삼조。방법이“염호저”，“불량반응”위검색사，검색중국기간전문수거고，안납입여배제표준공납입53편문헌，진행자료적제취여통계분석。결과인동환자발생솔고，루급계통-기관주요위피부급기부건손해、전신성손해、호흡계통손해등，불량반응이피진、발열、과민반응등최위상견，엄중가치과민성휴극。결론중시염호저주사제인기적불량반응，가강인동용약감측，방범불량반응발생，학보림상용약안전。
Objective Through investigating the characteristics and mechanism of adverse reactions induced by potassium sodium dehydroandrographolide succinate injection to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using "potassium sodium dehydroandrographolide succinate" and "adverse reaction"as key words to retrieve the CNKI database. Fifty-three articles which met the inclusion and exclusion criteria were extracted and analyzed. Results Pediatric patients appear to have higher ADR occurrence rate by using succinate injection. Systems and organs mainly involved in adverse reactions are skin and its appendages, systemic damage, respiratory damage, and etc. Rash, fever, and allergic reaction are the most common reported adverse reactions. Anaphylactic shock which is life threatening is also reported in several cases. Conclusion It is important to pay attention to the adverse reactions caused by potassium sodium dehydroandrographolidesuccinate injection, specially to strengthen pediatric postmarketing surveillance, in order to prevent adverse drug reactions and ensure the safe drug use in clinic.