CAJ | 학술논문

首先采用不同分子量的壳聚糖通过乳化-化学交联法制备了4种不同的壳聚糖载药微球。通过对微球的粒径、溶胀率、载药率、包封率等指标检测以及缓释性能的研究，发现分子量为240kDa的壳聚糖制备的载药微球缓释效果明显，载药率、包封率均较高，综合性能优于其它分子量壳聚糖制备的微球。利用该分子量壳聚糖包埋固态分散体制备了壳聚糖-固态分散体载药微球，改善了药物的溶解性并具有药物缓释作用。因此，壳聚糖-固态分散体载药微球是一种理想的药物缓释体系，可以用于包埋溶解性差，生物半衰期短，对胃肠刺激性强的药物。
수선채용불동분자량적각취당통과유화-화학교련법제비료4충불동적각취당재약미구。통과대미구적립경、용창솔、재약솔、포봉솔등지표검측이급완석성능적연구，발현분자량위240kDa적각취당제비적재약미구완석효과명현，재약솔、포봉솔균교고，종합성능우우기타분자량각취당제비적미구。이용해분자량각취당포매고태분산체제비료각취당-고태분산체재약미구，개선료약물적용해성병구유약물완석작용。인차，각취당-고태분산체재약미구시일충이상적약물완석체계，가이용우포매용해성차，생물반쇠기단，대위장자격성강적약물。
In the present work, four kinds of chitosan-based microspheres with different molecular weight of chi- tosan were prepared by emulsion-chemical crosslinking method. The characterizations of the microspheres were investigated regarding mean particle size, swelling ratio, drug-loading efficiency, encapsulation efficiency and performance of slow-release. The results indicated that the microspheres prepared with 240kDa of chitosan had higher drug-loading efficiency, higher encapsulation efficiency and more slowly released speed than the other mi- crospheres. The chitosan-solid dispersion microspheres prepared with 240kDa of chitosan increased the solubili- ty of ibuprofen and decreased the speed of drug release. The results revealed that the chitosan-solid dispersion microspheres had potential applications in drug release systems.