中华儿科杂志
中華兒科雜誌
중화인과잡지
Chinese Journal of Pediatrics
2013年
12期
892-897
,共6页
周丽卿%陈静%胡燕%黎海芪
週麗卿%陳靜%鬍燕%黎海芪
주려경%진정%호연%려해기
食物过敏%季节%皮肤点刺试验
食物過敏%季節%皮膚點刺試驗
식물과민%계절%피부점자시험
Food allergy%Seasons%Skin prick test
目的 研究季节对诊断婴幼儿食物过敏的影响.方法 分析2009年重庆医科大学附属儿童医院儿童保健科健康体检婴幼儿随机进行食物过敏调查的资料,冬季603例和夏季607例,包括病史问卷、皮肤点刺试验(SPT)、食物排除试验以及口服食物激发试验(OFC)结果.采用统计软件SPSS 17.0对数据进行录入分析.结果 冬、夏季二次食物过s敏调查的婴幼儿年龄、性别及失访情况差异无统计学意义.冬季调查603例婴幼儿中SPT(+)90例、OFC(+)40例、失访31例；夏季调查607例婴幼儿中SPT(+)65例、OFC(+)25例、失访31例.冬、夏季二次婴幼儿食物过敏调查SPT结果对诊断食物过敏的敏感度(85％vs.84％)、阳性预测值(PPV)(54％vs.47％)和阴性预测值(NPV)(99％vs.99％)差异无统计学意义；冬季调查组SPT结果阳性婴幼儿(14.9％,90/603)显著高于夏季调查组(10.7％,65/607)(P=0.028).冬季婴幼儿食物过敏确诊率(7.0％,40/572)高于夏季食物过敏确诊率(4.3％,25/575),但差异无统计学意义；矫正后冬季婴幼儿食物过敏检出率则高于夏季组(9.3％vs.5.9％)(P=0.028).圆形分布结果显示冬、夏季二次婴幼儿食物过敏调查SPT和OFC阳性率高峰点估计值对应出生日期均不一致,SPT和OFC结果与婴幼儿出生季节无关.结论 婴幼儿SPT结果与季节有关,食物过敏发生可能与季节有关.SPT和OFC结果与婴幼儿出生季节无关,与调查时儿童的实际年龄有关.
目的 研究季節對診斷嬰幼兒食物過敏的影響.方法 分析2009年重慶醫科大學附屬兒童醫院兒童保健科健康體檢嬰幼兒隨機進行食物過敏調查的資料,鼕季603例和夏季607例,包括病史問捲、皮膚點刺試驗(SPT)、食物排除試驗以及口服食物激髮試驗(OFC)結果.採用統計軟件SPSS 17.0對數據進行錄入分析.結果 鼕、夏季二次食物過s敏調查的嬰幼兒年齡、性彆及失訪情況差異無統計學意義.鼕季調查603例嬰幼兒中SPT(+)90例、OFC(+)40例、失訪31例；夏季調查607例嬰幼兒中SPT(+)65例、OFC(+)25例、失訪31例.鼕、夏季二次嬰幼兒食物過敏調查SPT結果對診斷食物過敏的敏感度(85％vs.84％)、暘性預測值(PPV)(54％vs.47％)和陰性預測值(NPV)(99％vs.99％)差異無統計學意義；鼕季調查組SPT結果暘性嬰幼兒(14.9％,90/603)顯著高于夏季調查組(10.7％,65/607)(P=0.028).鼕季嬰幼兒食物過敏確診率(7.0％,40/572)高于夏季食物過敏確診率(4.3％,25/575),但差異無統計學意義；矯正後鼕季嬰幼兒食物過敏檢齣率則高于夏季組(9.3％vs.5.9％)(P=0.028).圓形分佈結果顯示鼕、夏季二次嬰幼兒食物過敏調查SPT和OFC暘性率高峰點估計值對應齣生日期均不一緻,SPT和OFC結果與嬰幼兒齣生季節無關.結論 嬰幼兒SPT結果與季節有關,食物過敏髮生可能與季節有關.SPT和OFC結果與嬰幼兒齣生季節無關,與調查時兒童的實際年齡有關.
목적 연구계절대진단영유인식물과민적영향.방법 분석2009년중경의과대학부속인동의원인동보건과건강체검영유인수궤진행식물과민조사적자료,동계603례화하계607례,포괄병사문권、피부점자시험(SPT)、식물배제시험이급구복식물격발시험(OFC)결과.채용통계연건SPSS 17.0대수거진행록입분석.결과 동、하계이차식물과s민조사적영유인년령、성별급실방정황차이무통계학의의.동계조사603례영유인중SPT(+)90례、OFC(+)40례、실방31례；하계조사607례영유인중SPT(+)65례、OFC(+)25례、실방31례.동、하계이차영유인식물과민조사SPT결과대진단식물과민적민감도(85％vs.84％)、양성예측치(PPV)(54％vs.47％)화음성예측치(NPV)(99％vs.99％)차이무통계학의의；동계조사조SPT결과양성영유인(14.9％,90/603)현저고우하계조사조(10.7％,65/607)(P=0.028).동계영유인식물과민학진솔(7.0％,40/572)고우하계식물과민학진솔(4.3％,25/575),단차이무통계학의의；교정후동계영유인식물과민검출솔칙고우하계조(9.3％vs.5.9％)(P=0.028).원형분포결과현시동、하계이차영유인식물과민조사SPT화OFC양성솔고봉점고계치대응출생일기균불일치,SPT화OFC결과여영유인출생계절무관.결론 영유인SPT결과여계절유관,식물과민발생가능여계절유관.SPT화OFC결과여영유인출생계절무관,여조사시인동적실제년령유관.
Objective To investigate the seasonal influence on the diagnosis of food allergy in children under 3 years of age.Method The data of epidemiological studies about food allergy of children under 3 years of age attending routine well-baby checks at the Department of Primary Child Care,Children's Hospital of Chongqing Medical University in the winter and summer,2009,including questionnaires,results of skin prick test (SPT),food elimination and oral food challenge (OFC) were analyzed.All the data were analyzed by SPSS 17.0.Result The age and sex distribution,and both the rates of the drop-out in two studies were similar.Ninety infants were positive for SPT,40 infants were positive for OFC,and 31 infants dropped out in winter; while 65 infants were positive for SPT,25 positive for OFC,and 31 dropped out in summer.The percentage of positive SPT in the children performed in winter was higher than that in summer (14.9％,90/603 vs 10.7％,65/607) (P =0.028).Skin prick test accuracy was similar when the studies were performed in winter and in summer [sensitivity 0.85 and 0.84,positive predictive value (PPV) 0.54and 0.47,negative predictive value (NPV) 0.99 and 0.99].The prevalence of food allergy in the children studied in winter was higher than that in summer (7.0％ vs 4.3％),but the difference was not significant.After correcting the prevalence for dropout children,the prevalence of food allergy (FA)investigated in winter was significantly higher than that in summer (9.3％ vs 5.9％).The results of circular distribution analysis showed the date of birth corresponding to estimated value of peak point of SPT in winter were not consistent with it in summer,so was OFC.Either the results of skin prick test or oral food challenge in two studies were not correlated with the seasons of birth.Conclusion Our data showed that the rates of positive SPT and the prevalence of food allergy were correlated with the seasons,but the seasons of birth did not influence the results of skin prick test or oral food challenge in children,while the real age of children were related to them.
