CAJ | 학술논문

选用壳聚糖与透明质酸复合,采用喷雾干燥的方法制备了壳聚糖-透明质酸水凝胶微球。扫描电镜观察结果显示微球分散均匀,尺寸在1～2μm范围。微球能够在15min内达到溶胀平衡,溶胀率达30倍。体外凝血实验及动物实验结果显示该材料具有良好的止血、防粘连特性,对正常鼻粘膜无严重负面影响,其使用安全性明显优于目前临床上广泛应用的填塞型鼻用止血材料。
선용각취당여투명질산복합,채용분무간조적방법제비료각취당-투명질산수응효미구。소묘전경관찰결과현시미구분산균균,척촌재1～2μm범위。미구능구재15min내체도용창평형,용창솔체30배。체외응혈실험급동물실험결과현시해재료구유량호적지혈、방점련특성,대정상비점막무엄중부면영향,기사용안전성명현우우목전림상상엄범응용적전새형비용지혈재료。
Hemostasis is one common problem in otolaryngology.Hydrogels derived from natural proteins and polysaccharides are ideal hemostatic materials since they resemble the extracellular matrices of the tissue comprising various amino acids and sugar based macromolecules.The hydrogel microspheres based on chitosan and hyaluronic by the spray-drying method was presented in this work.Perfectly spherical hydrogel microspheres were obtained in the size range of 1-2μm.The microspheres reached the balance swelling within 15min,and the swelling ratio reached 30 times of the original.The animal test showed that there was little serious negative effect of the Chi-HA microspheres on the normal nasal mucosa.And the Chi-HA microspheres were more safety than sponge when used in packing nasal cavity.