功能材料
功能材料
공능재료
JOURNAL OF FUNCTIONAL MATERIALS
2012年
22期
3092-3096
,共5页
肖秀峰%梁建鹤%汤海贞%杨小娟%刘榕芳
肖秀峰%樑建鶴%湯海貞%楊小娟%劉榕芳
초수봉%량건학%탕해정%양소연%류용방
电化学阳极氧化法%TiO2纳米管阵列%牛血清白蛋白
電化學暘極氧化法%TiO2納米管陣列%牛血清白蛋白
전화학양겁양화법%TiO2납미관진렬%우혈청백단백
anodic oxidation%TiO2 nanotube arrays%bovine serum albumin
采用电化学阳极氧化法以含氟的乙二醇溶液为电解液阳极氧化纯钛制备出排列规则的高长径比TiO2纳米管阵列膜,并用扫描电镜（SEM）、比表面积仪表征了TiO2纳米管阵列膜的形貌和比表面积。结果表明,所制得的TiO2纳米管阵列的管径约180nm,管长可达230μm,比表面积约59.8m2/g。以牛血清白蛋白（BSA）为药物蛋白分子的模型,并研究了TiO2纳米管阵列膜对BSA的吸附和脱附行为,考察了溶液pH值、BSA初始浓度和溶液离子强度对BSA吸附的影响与吸附态的BSA在不同pH值的PBS溶液中的释放行为。结果表明,BSA分子在其等电点（pH值=4.8）附近较容易吸附到TiO2纳米管上,吸附量随着BSA初始浓度的增加而增加,较高的离子强度会降低BSA的吸附,碱性条件下吸附态的BSA容易从TiO2纳米管上脱附,并由于纳米管的扩散限制效益呈现一定程度的缓释。
採用電化學暘極氧化法以含氟的乙二醇溶液為電解液暘極氧化純鈦製備齣排列規則的高長徑比TiO2納米管陣列膜,併用掃描電鏡（SEM）、比錶麵積儀錶徵瞭TiO2納米管陣列膜的形貌和比錶麵積。結果錶明,所製得的TiO2納米管陣列的管徑約180nm,管長可達230μm,比錶麵積約59.8m2/g。以牛血清白蛋白（BSA）為藥物蛋白分子的模型,併研究瞭TiO2納米管陣列膜對BSA的吸附和脫附行為,攷察瞭溶液pH值、BSA初始濃度和溶液離子彊度對BSA吸附的影響與吸附態的BSA在不同pH值的PBS溶液中的釋放行為。結果錶明,BSA分子在其等電點（pH值=4.8）附近較容易吸附到TiO2納米管上,吸附量隨著BSA初始濃度的增加而增加,較高的離子彊度會降低BSA的吸附,堿性條件下吸附態的BSA容易從TiO2納米管上脫附,併由于納米管的擴散限製效益呈現一定程度的緩釋。
채용전화학양겁양화법이함불적을이순용액위전해액양겁양화순태제비출배렬규칙적고장경비TiO2납미관진렬막,병용소묘전경（SEM）、비표면적의표정료TiO2납미관진렬막적형모화비표면적。결과표명,소제득적TiO2납미관진렬적관경약180nm,관장가체230μm,비표면적약59.8m2/g。이우혈청백단백（BSA）위약물단백분자적모형,병연구료TiO2납미관진렬막대BSA적흡부화탈부행위,고찰료용액pH치、BSA초시농도화용액리자강도대BSA흡부적영향여흡부태적BSA재불동pH치적PBS용액중적석방행위。결과표명,BSA분자재기등전점（pH치=4.8）부근교용역흡부도TiO2납미관상,흡부량수착BSA초시농도적증가이증가,교고적리자강도회강저BSA적흡부,감성조건하흡부태적BSA용역종TiO2납미관상탈부,병유우납미관적확산한제효익정현일정정도적완석。
Highly ordered and uniform TiO2 nanotube arrays were fabricated by anodic oxidation of titanium foil in ethylene glycol containing NH, F and deionized water. The morphology and surface area of TiO2 nanotube arrays were characterized by scanning electron microscope(SEM) and specific surface area measuring instrument, respectively. The diameter, the length and the surface area of TiO2 nanotube arrays are, about 180nm, over 230f, m and 59.8m2/g, respectively. Then, the adsorption and desorption behavior of bovine serum albumin on TiO2 nanotube arrays were investigated. The results showed that the adsorption ability of bovine serum albumin was affected by pH value, initial concentration of BSA and ionic strength, respectively. The desorption of bovine serum albumin from TiO2 nanotube arrays were affected by pH value of PBS. Bovine serum albumin eas ily released from TiO2 nanotube arrays in alkaline conditions, and appeared diffusion limited benefits.
