CAJ | 학술논문

以戊二酸锌为催化剂合成可降解聚碳酸亚丙亚乙酯（PPEC,MW=229.338kDa）并首次将其作为载药涂层材料进行研究。核磁共振氢谱（1 H NMR）显示分子链中环氧乙烷和环氧丙烷的贡献与原料中两者配比相同,碳酸酯段含量为76.7%。差示扫描量热仪（DSC）测得玻璃化转变温度（Tg）为16.8℃。拉伸实验得到断裂伸长率为550%。衰减全反射-傅立叶变换红外光谱（ATR-FT-IR）显示药物涂层中PPEC和雷帕霉素之间没有发生明显的化学反应。球囊扩张实验后用扫描电子显微镜（SEM）观察到药物涂层支架表面完整光滑,没有剥落翘起的现象。药物洗脱支架在模拟体液（PBS,pH值=7.4）中药物释放时间超过60d,速率由快变慢。实验表明PPEC作为支架涂层材料具有广阔的应用前景。
이무이산자위최화제합성가강해취탄산아병아을지（PPEC,MW=229.338kDa）병수차장기작위재약도층재료진행연구。핵자공진경보（1 H NMR）현시분자련중배양을완화배양병완적공헌여원료중량자배비상동,탄산지단함량위76.7%。차시소묘량열의（DSC）측득파리화전변온도（Tg）위16.8℃。랍신실험득도단렬신장솔위550%。쇠감전반사-부립협변환홍외광보（ATR-FT-IR）현시약물도층중PPEC화뢰파매소지간몰유발생명현적화학반응。구낭확장실험후용소묘전자현미경（SEM）관찰도약물도층지가표면완정광활,몰유박락교기적현상。약물세탈지가재모의체액（PBS,pH치=7.4）중약물석방시간초과60d,속솔유쾌변만。실험표명PPEC작위지가도층재료구유엄활적응용전경。
The biodegradable poly（propylene ethylene carbonate）（PPEC,M w =229.338kDa） was synthesized using zinc glutarate catalyst and investigated as drug-loaded coating materials for the first time in this paper.1 H NMR spectra show the contribution of ethylene oxide and propylene oxide is 6∶4and the carbonate content is 76.7%in PPEC molecular formula.The elongation at break is 550%by stress-strain test.Attenuated total reflectance-infrared spectroscopy（ATR-FT-IR） analysis of sirolimus,PPEC and sirolimus-loaded PPEC coating show that no chemical reactions happene between sirolimus and PPEC.After balloon expansion experiment,no delamination or destruction of the coating is observed by SEM.In vitro drug release behavior reveals that drug release of drug-eluting stent is over 60days in PBS（0.05mol / L,pH =7.4） solution.All the experiment results show that PPEC as a stent coating materials has broad application prospects.