CAJ | 학술논문

通过自由基聚合反应将马来酸酐接枝到聚（D,L-乳酸）（PDLLA）侧链上,然后通过引入的活性反应基团马来酸酐与甘油磷脂胆碱反应,实现磷脂胆碱对聚乳酸的整体仿生修饰。采用红外光谱和核磁共振碳谱对磷脂胆碱修饰聚乳酸进行了表征。生物降解实验表明,该功能化聚乳酸具有明显抑制酸致降解作用。体外细胞形貌观察证实磷脂胆碱修饰的聚乳酸具有良好的细胞相容性。同时,蛋白吸附和血小板粘附实验表明,该聚合物具有良好的血液相容性。该改性聚乳酸可望用作组织工程支架及血液接触类植入体。
통과자유기취합반응장마래산항접지도취（D,L-유산）（PDLLA）측련상,연후통과인입적활성반응기단마래산항여감유린지담감반응,실현린지담감대취유산적정체방생수식。채용홍외광보화핵자공진탄보대린지담감수식취유산진행료표정。생물강해실험표명,해공능화취유산구유명현억제산치강해작용。체외세포형모관찰증실린지담감수식적취유산구유량호적세포상용성。동시,단백흡부화혈소판점부실험표명,해취합물구유량호적혈액상용성。해개성취유산가망용작조직공정지가급혈액접촉류식입체。
The maleic anhydride is grafted onto the side-chain of poly（D, L-lactic acid）（PDLLA）by free radical polymerization firstly. Secondly the maleic anhydride is reacted with glycerophosphorylcholine（GPC）. Thus the phospholipid choline bionic chemical modification with PDLLA can be got. It was characterized by fourier trans- form infrared spectroscopy （FT-IR）and^13 C-NMR. Biodegradation test showed that this functional poly（D, L- lactic acid） could significantly inhibit＇the acid induced degradation of the PDLLA. In vitro cell morphology ob- servation confirmed that GPC modified PDLLA was cytocompatible. Meanwhile, Protein adsorption test and platelet adhesion test revealed that the GPC modified PDLLA was also hemocompatible. These results suggest that GPC modified PDLLA could be an excellent biocompatible candidate for the development of tissue engineer- ing scaffold and blood contacting implants.