CAJ | 학술논문

以6-氨基己酸（6-aminohexanoic acid,N6）和丁内酰胺（又名α-吡咯烷酮,α-pyrrolidone,α-P）为原料,通过6-氨基己酸熔融缩聚使丁内酰胺开环制备了一系列新型聚酰胺,优化选取6-氨基己酸与丁内酰胺摩尔比为7∶3的聚合物作为基体与硫酸钙（CS）复合,制备了新型可降解硫酸钙/聚酰胺复合材料。通过乌氏粘度计、万能力学实验机、红外光谱（IR）、差示扫描量热分析（DSC）、X射线衍射（XRD）和X光电子能谱（XPS）对其特性黏数、抗压强度及组成与结构进行了表征,并研究了复合材料在磷酸缓冲溶液（PBS）的体外降解性能。结果表明产物为具有酰胺键结构的聚合物,6-氨基己酸与丁内酰胺摩尔比为7∶3时聚合物既能最大程度地引入丁内酰胺又具有较好的力学性能。复合材料无机相与有机相之间存在化学键作用。体外降解实验表明本文合成的聚酰胺是可降解的;相比于聚合物,硫酸钙/聚酰胺复合材料具有更快的降解速率;随着硫酸钙含量的增加,复合材料的失重率增加;在降解过程中降解液pH值维持在6.6～7.4之间。由于复合材料既具备有机组分良好的力学性能又具备硫酸钙良好的生物相容性和降解性能,所以该硫酸钙/聚酰胺复合材料可望在骨修复领域得到运用。
이6-안기기산（6-aminohexanoic acid,N6）화정내선알（우명α-필각완동,α-pyrrolidone,α-P）위원료,통과6-안기기산용융축취사정내선알개배제비료일계렬신형취선알,우화선취6-안기기산여정내선알마이비위7∶3적취합물작위기체여류산개（CS）복합,제비료신형가강해류산개/취선알복합재료。통과오씨점도계、만능역학실험궤、홍외광보（IR）、차시소묘량열분석（DSC）、X사선연사（XRD）화X광전자능보（XPS）대기특성점수、항압강도급조성여결구진행료표정,병연구료복합재료재린산완충용액（PBS）적체외강해성능。결과표명산물위구유선알건결구적취합물,6-안기기산여정내선알마이비위7∶3시취합물기능최대정도지인입정내선알우구유교호적역학성능。복합재료무궤상여유궤상지간존재화학건작용。체외강해실험표명본문합성적취선알시가강해적;상비우취합물,류산개/취선알복합재료구유경쾌적강해속솔;수착류산개함량적증가,복합재료적실중솔증가;재강해과정중강해액pH치유지재6.6～7.4지간。유우복합재료기구비유궤조분량호적역학성능우구비류산개량호적생물상용성화강해성능,소이해류산개/취선알복합재료가망재골수복영역득도운용。
A novel biodegradable polyamide was prepared by in ring opening melting polymerization based on 6- aminocaproic acid and a-pyrrolidone, then N6P30 （when the molar ratio of 6-aminocaproic acid and a-pyrroli- done is 7 ： 3） and its composite material with calcium sulfate （CS/N6P30） was synthesized. They were characterized by infrared spectrometer （IR）, X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS） and differential scanning calorimeter （DSC）. Its properties of the viscosity of polymer were investigated by means of ubbelohde viscometer the mechanical properties were characterized by compressive strength and the in vitro degradability of the composite was determined in phosphate buffered saline （PBS）. The results indicated that the polymer was a kind of polyamide, the reaction become more and more difficult with increasing of the proportion of a-pyrrolidone, it has both good mechanical property and the greatest degree of introduction of a-pyrrolidone when the molar ratio of 6-aminocaproic acid and a-pyrroiidone was 7 ：3. PBS experiment indicated that CS/N6P30 was more degradable than N6P30~ degradability of composite materials enhanced with increasing calcium sulfate amount; the pH of soaking medium maintained in the range of 6.6-7.4 during the immersion period. Composite material not only has the good mechanical properties as that of N6P30, but also the biocompatibility as that of CS,so this composite can be potentially used as bone repair materials.