CAJ | 학술논문

分别采用0、2％、49／5、8％、16％（质量分数）的京尼平（GP）交联脱细胞猪真皮基质（pADM），检测交联后材料（GP—pADM）的基本性能。研究结果表明，随着交联剂GP用量的增加，材料的收缩温度逐渐提高，抗张强度降低；电镜扫描图显示交联后材料的孔隙有缩小的趋势，并导致了吸附水率、吸湿率和溶胀率的逐渐下降；红外图谱表明交联后材料中含有共轭双键；细胞毒性试验显示，GP—pADM细胞毒性为0级，急性经口毒性实验未见明显急性毒性。
분별채용0、2％、49／5、8％、16％（질량분수）적경니평（GP）교련탈세포저진피기질（pADM），검측교련후재료（GP—pADM）적기본성능。연구결과표명，수착교련제GP용량적증가，재료적수축온도축점제고，항장강도강저；전경소묘도현시교련후재료적공극유축소적추세，병도치료흡부수솔、흡습솔화용창솔적축점하강；홍외도보표명교련후재료중함유공액쌍건；세포독성시험현시，GP—pADM세포독성위0급，급성경구독성실험미견명현급성독성。
Porcine acellular dermal matrix (pADM) was crosslinked by serial dosage 0, 2~, 4~, 6%, 8%, 16wt% of genipin (GP) respectively, and the properties of which were characterized with shrinkage temperature (Ts), rate of hydroscopicity, adhered water, absorbtion water, FT-IR, and SEM before and after crosslinked. With the increase of GP concentration, Ts of GP-pADM was enhanced obviously, but tensile strength declined. Observed from the SEM images of the material surface, the holes of GP-pADM tended to shrink after crosslinked, which resulted in the fall of the rate of hydroscopicity, adhered water, absorbtion water. Conjugated bouble-bonds were discovered and formed a new absorption in 2358.48cm^-1 after crosslinking. Acute oral toxicity did not appear and cytotoxicity of extraction obtainted from them respectively didn't observe in L-929 fibroblasts cultivated experiment. It was concluded that genipin was a superior crosslink agent for pADM.