CAJ | 학술논문

目的：探讨血清Tau蛋白水平与脑出血（ ICH）患者早期预后的关系。方法回顾性分析274例自发的脑出血患者的病历资料，收集患者入院时的一般资料、病史、临床资料以及影像学特点等指标，采用GOS评分对患者出院时情况进行评分，分为预后良好组（ GOS 4～5分）和预后不良组（ GOS 1～3分）。结果274例患者中145例患者预后良好，占总人数的52．9％，129例预后不良，占47．1％。预后不良组入院时血清Tau蛋白（394．7±29．6 pg／ml）明显高于预后良好组（201．2±18．5 pg／ml）。血清高Tau蛋白水平与不良预后相关。结论在ICH患者中，入院时血清高Tau蛋白水平是预后不良的强预测因素。
목적：탐토혈청Tau단백수평여뇌출혈（ ICH）환자조기예후적관계。방법회고성분석274례자발적뇌출혈환자적병력자료，수집환자입원시적일반자료、병사、림상자료이급영상학특점등지표，채용GOS평분대환자출원시정황진행평분，분위예후량호조（ GOS 4～5분）화예후불량조（ GOS 1～3분）。결과274례환자중145례환자예후량호，점총인수적52．9％，129례예후불량，점47．1％。예후불량조입원시혈청Tau단백（394．7±29．6 pg／ml）명현고우예후량호조（201．2±18．5 pg／ml）。혈청고Tau단백수평여불량예후상관。결론재ICH환자중，입원시혈청고Tau단백수평시예후불량적강예측인소。
Objective To explore the relationship between Tau protein and outcome of acute intracerebral hemorrhage(ICH).Methods The clinical data of 274 patients with acute ICH were analyzed retrospectively.The general informations of patients on admission, medical history, clinical data and imaging features were collected.The patients were divided into good outcome group ( GOS 4-5) and poor outcome group ( GOS 1-3 ) using the Glasgow Outcome Rating Scale ( GOS ) of discharged patients.Results Of 274 patients, 145 had a good outcome, accounting for 52.9% of the total number and 129 poor outcome, accounting for 47.1%.In poor outcome group (394.7 ± 29.6 pg/ml) initial Serum Tau protein level was significantly higher than that in the good outcome group (201.2 ±18.5pg/ml).High Tau protein level was associated with poor outcome.Conclusion In patients with acute ICH, admission high Tau protein is strong predictor of a poor prognosis.