中国药事
中國藥事
중국약사
CHINESE PHARMACEUTICAL AFFAIRS
2014年
11期
1257-1260
,共4页
李樾%杨会英%王峰%孙会敏
李樾%楊會英%王峰%孫會敏
리월%양회영%왕봉%손회민
药包材%卤化丁基橡胶塞%硫化剂残留检测%可提取硫检测%高效液相色谱法
藥包材%滷化丁基橡膠塞%硫化劑殘留檢測%可提取硫檢測%高效液相色譜法
약포재%서화정기상효새%류화제잔류검측%가제취류검측%고효액상색보법
pharmaceutical packaging material%halogenated butyl rubber%detection of the residual vulcanizing agent%detection of extractable sulphur%HPLC
目的：建立药用卤化丁基橡胶塞中可提取硫的检测方法。方法以微波萃取的方式对样品进行前处理,采用高效液相色谱法,以 Agilent XDB-C18为色谱柱,甲醇-水(95∶5)为流动相,流速：1.0 mL·min-1,检测波长：264 nm。结果硫的检测线性范围为1~10μg·mL-1(r =0.9996)；平均回收率为95.2%, RSD=2.3%(n=9)。结论该方法经方法学验证,可用于考察药用卤化丁基橡胶塞中可提取硫的含量。
目的：建立藥用滷化丁基橡膠塞中可提取硫的檢測方法。方法以微波萃取的方式對樣品進行前處理,採用高效液相色譜法,以 Agilent XDB-C18為色譜柱,甲醇-水(95∶5)為流動相,流速：1.0 mL·min-1,檢測波長：264 nm。結果硫的檢測線性範圍為1~10μg·mL-1(r =0.9996)；平均迴收率為95.2%, RSD=2.3%(n=9)。結論該方法經方法學驗證,可用于攷察藥用滷化丁基橡膠塞中可提取硫的含量。
목적：건립약용서화정기상효새중가제취류적검측방법。방법이미파췌취적방식대양품진행전처리,채용고효액상색보법,이 Agilent XDB-C18위색보주,갑순-수(95∶5)위류동상,류속：1.0 mL·min-1,검측파장：264 nm。결과류적검측선성범위위1~10μg·mL-1(r =0.9996)；평균회수솔위95.2%, RSD=2.3%(n=9)。결론해방법경방법학험증,가용우고찰약용서화정기상효새중가제취류적함량。
Objective To establish a method for determining sulphur extracted from the medicinal halogenated butyl rubber.Methods The samples were preprocessed by microwave extraction.The column Agilent XDB-C18 was used for HPLC.The mobile phase consisted of methanol-water (95∶5).The flow rate was 1.0 mL · min-1 . The detection wavelength was 264 nm. Results The linearity range for extracted sulphur was from 1 to 10 μg·mL-1 (r =0.999 6 ).The average recovery assay was 95.2%, and the RSD was 2.3% (n=9).Conclusion The method is simple,rapid,accurate,and can be used to determine sulphur extracted from the medicinal halogenated butyl rubber.
