中国药事
中國藥事
중국약사
CHINESE PHARMACEUTICAL AFFAIRS
2014年
11期
1252-1256
,共5页
卡托普利片%卡托普利二硫化物%梯度洗脱%方法改进
卡託普利片%卡託普利二硫化物%梯度洗脫%方法改進
잡탁보리편%잡탁보리이류화물%제도세탈%방법개진
Captopril Tablet%captopril-disulphide%gradient elution%improvement of method
目的：探讨改进《中国药典》2010年版卡托普利片中卡托普利二硫化物的测定方法。方法以0.01 mol·L-1磷酸二氢钠-甲醇-乙腈(70∶25∶5)(用磷酸调节至 pH 3.0)为流动相 A,甲醇为流动相B；梯度洗脱。结果二硫化物的保留时间由药典方法的49.8 min 缩短到18.9 min。结论本文方法较药典方法快捷,可为标准改进提供参考。
目的：探討改進《中國藥典》2010年版卡託普利片中卡託普利二硫化物的測定方法。方法以0.01 mol·L-1燐痠二氫鈉-甲醇-乙腈(70∶25∶5)(用燐痠調節至 pH 3.0)為流動相 A,甲醇為流動相B；梯度洗脫。結果二硫化物的保留時間由藥典方法的49.8 min 縮短到18.9 min。結論本文方法較藥典方法快捷,可為標準改進提供參攷。
목적：탐토개진《중국약전》2010년판잡탁보리편중잡탁보리이류화물적측정방법。방법이0.01 mol·L-1린산이경납-갑순-을정(70∶25∶5)(용린산조절지 pH 3.0)위류동상 A,갑순위류동상B；제도세탈。결과이류화물적보류시간유약전방법적49.8 min 축단도18.9 min。결론본문방법교약전방법쾌첩,가위표준개진제공삼고。
Objective To discuss the improvement of testing for captopril-disulphide in Captopril Tablets in Chinese Pharmacopoeia (2010 edition).Methods The mobile phase A was 0.01 mol · L-1 sodium dihydrogen phosphate solution-methanol-acetonitrile (75 ∶ 25 ∶ 5 )(adjusted to pH 3.0 with phosphate);the mobile phase B was 100% methanol for gradient elution.Results The retention time of the disulphide was reduced from 49.8 min by pharmacopoeia method to 18.9 min by this method. Conclusion The method in this paper was quick and timesaving compared to the pharmacopoeia method, and can provide a reference for standard improvement.
