CAJ | 학술논문

目的：观察枸橼酸咖啡因治疗早产儿呼吸暂停的疗效。方法：选择妊娠26～32周出生、出生后24 h或更长一段时间呼吸暂停发作1次或1次以上的早产儿66例，按床位先后顺序分为2组，枸橼酸咖啡因组（观察组）33例，采用负荷量20 mg／kg（相当于咖啡因碱基10 mg／kg）静脉滴注（30 min），间隔24 h后给予5 mg／（ kg· d）[相当于咖啡因碱基2.5 mg／（ kg· d）]静脉滴注或口服；氨茶碱组（对照组）33例，采用首剂5.0 mg／kg静脉滴注，间隔8～12 h后给予1次2.0 mg／kg、2次／d，治疗5 d。结果：观察组治疗方案在降低呼吸暂停发病率方面与对照组的差异无统计学意义（P＞0.05）。结论：静脉注射枸橼酸咖啡因20 mg／kg（相当于咖啡因碱基10 mg／kg），后续5 d静脉注射或口服枸橼酸咖啡因5 mg／（ kg· d）[相当于咖啡因碱基2.5 mg／（ kg· d）]，对治疗妊娠26～32周的早产儿呼吸暂停的疗效与氨茶碱相当。
목적：관찰구연산가배인치료조산인호흡잠정적료효。방법：선택임신26～32주출생、출생후24 h혹경장일단시간호흡잠정발작1차혹1차이상적조산인66례，안상위선후순서분위2조，구연산가배인조（관찰조）33례，채용부하량20 mg／kg（상당우가배인감기10 mg／kg）정맥적주（30 min），간격24 h후급여5 mg／（ kg· d）[상당우가배인감기2.5 mg／（ kg· d）]정맥적주혹구복；안다감조（대조조）33례，채용수제5.0 mg／kg정맥적주，간격8～12 h후급여1차2.0 mg／kg、2차／d，치료5 d。결과：관찰조치료방안재강저호흡잠정발병솔방면여대조조적차이무통계학의의（P＞0.05）。결론：정맥주사구연산가배인20 mg／kg（상당우가배인감기10 mg／kg），후속5 d정맥주사혹구복구연산가배인5 mg／（ kg· d）[상당우가배인감기2.5 mg／（ kg· d）]，대치료임신26～32주적조산인호흡잠정적료효여안다감상당。
OBJECTIVE:To evaluate the efficacy of caffeine citrate for apnea of prematurity.METHODS:A total of 66 premature infants at gestational age of 26 to 32 weeks with apnea attack of at least one time within 24 hrs or longer after birth were enrolled, with 33 assigned to observation group treated with citrated caffeine at load dosage of 20 mg/kg ( caffeine base 10 mg/kg) by intravenous infusion (30 min) , 24 hrs later, then the patients were administered intravenously or orally with citrated caffeine at dosage of 5 mg/(kg· d)[caffeine base 2.5 mg/(kg· d)], another 33 were assigned to control group treated intravenously with aminophylline at initial dose of 5.0 mg/kg, 8-12 hours later, these patients were treated with aminophylline at dosage of 2.0 mg/kg bid for 5 days.RESULTS: There was more reduction in the incidence of apnea in the observation group than in the control group, but the differences between the two groups were not statistically significant (P>0.05).CONCLUSIONS: Caffeine citrate administered intravenously at a dose of 20 mg/kg ( equivalent to caffeine base 10 mg/kg) followed by intravenous or oral administration at dosage of 5 mg/( kg· d) [ equivalent to caffeine base base 2.5 mg/( kg· d) ] for 5 days is as effective as theophylline for apnea of prematurity in the premature infants born after gestation of 26 to 32 weeks.