中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2014年
11期
972-974
,共3页
李戈辉%亚杰%李元涛%孙晶%齐晓非%王晓光
李戈輝%亞傑%李元濤%孫晶%齊曉非%王曉光
리과휘%아걸%리원도%손정%제효비%왕효광
七氟醚%恶心%呕吐%地塞米松%昂丹司琼
七氟醚%噁心%嘔吐%地塞米鬆%昂丹司瓊
칠불미%악심%구토%지새미송%앙단사경
Evoflurane%Nausea and vomiting%Dexamethasone%Ondansetron
目的：观察地塞米松联合昂丹司琼预防七氟醚全麻术后恶心、呕吐的临床疗效。方法：将240例择期拟行全麻腹腔镜术的妇科患者按随机数字表法分为4组，每组60例，分别为对照组（A组，不用止吐药）、地塞米松组（B组）、昂丹司琼组（C组）和地塞米松＋昂丹司琼组（D组），观察并比较4组患者在术后24 h内出现恶心、呕吐的情况。结果：4组患者的术后恶心、呕吐分级不全相同（Hc＝33.590，P＜0.05），B、C、D组患者术后恶心、呕吐的发生率均低于A组（P＜0.0083），B组与C组的差异无统计学意义（χ2＝0.082，P＞0.05），B、C组也均高于D组（P＜0.0125）。结论：地塞米松和昂丹司琼均能较好预防术后恶心、呕吐，2药联合应用具有协同作用，比单一应用的效果更佳。
目的：觀察地塞米鬆聯閤昂丹司瓊預防七氟醚全痳術後噁心、嘔吐的臨床療效。方法：將240例擇期擬行全痳腹腔鏡術的婦科患者按隨機數字錶法分為4組，每組60例，分彆為對照組（A組，不用止吐藥）、地塞米鬆組（B組）、昂丹司瓊組（C組）和地塞米鬆＋昂丹司瓊組（D組），觀察併比較4組患者在術後24 h內齣現噁心、嘔吐的情況。結果：4組患者的術後噁心、嘔吐分級不全相同（Hc＝33.590，P＜0.05），B、C、D組患者術後噁心、嘔吐的髮生率均低于A組（P＜0.0083），B組與C組的差異無統計學意義（χ2＝0.082，P＞0.05），B、C組也均高于D組（P＜0.0125）。結論：地塞米鬆和昂丹司瓊均能較好預防術後噁心、嘔吐，2藥聯閤應用具有協同作用，比單一應用的效果更佳。
목적：관찰지새미송연합앙단사경예방칠불미전마술후악심、구토적림상료효。방법：장240례택기의행전마복강경술적부과환자안수궤수자표법분위4조，매조60례，분별위대조조（A조，불용지토약）、지새미송조（B조）、앙단사경조（C조）화지새미송＋앙단사경조（D조），관찰병비교4조환자재술후24 h내출현악심、구토적정황。결과：4조환자적술후악심、구토분급불전상동（Hc＝33.590，P＜0.05），B、C、D조환자술후악심、구토적발생솔균저우A조（P＜0.0083），B조여C조적차이무통계학의의（χ2＝0.082，P＞0.05），B、C조야균고우D조（P＜0.0125）。결론：지새미송화앙단사경균능교호예방술후악심、구토，2약연합응용구유협동작용，비단일응용적효과경가。
OBJECTIVE:To evaluate the clinical preventive efficacy of dexamethasone plus ondansetron against postoperative nausea and vomiting ( PONV) following general anesthesia using sevoflurane.METHODS:A total of 240 gynecological patients undergoing laparoscopy plus general anesthesia were randomly divided into four groups of 60 each with random number table method, i.e., Group A ( control group) received no antiemetics; Group B received dexamethasone;Group C received ondansetron, and Group D received dexamethasone plus ondansetron.PONV on the first postoperative day ( within 24 hours) was recorded and compared among the four groups.RESULTS:The grading of PONV ( Hc=33.590 , P<0.05 ) was not totally the same among the four groups ( c =33.590 , P<0.05 ); the incidences of PONV in the experimental groups (Group B, C and D) were all higher than in Group A (P<0.008 3), yet there were no statistical significance between group B and C ( P>0.05);the incidences of PONV in Group B and C were higher than in Group D ( P <0.012 5 ) , which was thought be the joint action of dexamethasone and ondansetron against PONV after general anesthesia with sevoflurane. CONCLUSIONS: Either dexamethasone or ondansetron showed satisfactory preventive efficacy against PONV; dexamethasone and ondansetron had better preventive efficacy against PONV if used in combination as compared with used alone.
