中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
11期
1395-1395,1397
,共2页
维生素D受体基因多态性%2型糖尿病%骨密度%关系
維生素D受體基因多態性%2型糖尿病%骨密度%關繫
유생소D수체기인다태성%2형당뇨병%골밀도%관계
Vitamin D receptor gene polymorphism%Type 2 diabetes%Bone density%Relations
目的：研究维生素D受体基因多态性与2型糖尿病(DM)骨密度两者之间的关系。方法：选取我院50例DM患者作为观察组，50例健康体检者作为对照组，比较两组BsmI的等位基因变化情况。结果：维生素D中的等位基因B和b，两组患者有明显的差异，观察组基因频率分别为40%、60%，对照组基因频率为20%、80%，观察组基因型频率为15%、45%、和35%，对照组为10%、30%和65%。等位基因与2型DM有着紧密的联系，等位基因B能够有效保护2型DM，等位基因b是2型DM发病的主要原因之一。结论：维生素D受体基因多态性与2型DM骨密度有很大的关联，等位基因b更是引发2型DM的主要基因。
目的：研究維生素D受體基因多態性與2型糖尿病(DM)骨密度兩者之間的關繫。方法：選取我院50例DM患者作為觀察組，50例健康體檢者作為對照組，比較兩組BsmI的等位基因變化情況。結果：維生素D中的等位基因B和b，兩組患者有明顯的差異，觀察組基因頻率分彆為40%、60%，對照組基因頻率為20%、80%，觀察組基因型頻率為15%、45%、和35%，對照組為10%、30%和65%。等位基因與2型DM有著緊密的聯繫，等位基因B能夠有效保護2型DM，等位基因b是2型DM髮病的主要原因之一。結論：維生素D受體基因多態性與2型DM骨密度有很大的關聯，等位基因b更是引髮2型DM的主要基因。
목적：연구유생소D수체기인다태성여2형당뇨병(DM)골밀도량자지간적관계。방법：선취아원50례DM환자작위관찰조，50례건강체검자작위대조조，비교량조BsmI적등위기인변화정황。결과：유생소D중적등위기인B화b，량조환자유명현적차이，관찰조기인빈솔분별위40%、60%，대조조기인빈솔위20%、80%，관찰조기인형빈솔위15%、45%、화35%，대조조위10%、30%화65%。등위기인여2형DM유착긴밀적련계，등위기인B능구유효보호2형DM，등위기인b시2형DM발병적주요원인지일。결론：유생소D수체기인다태성여2형DM골밀도유흔대적관련，등위기인b경시인발2형DM적주요기인。
[ABSTRACT]Objective:To study t he relationship between vitamin D receptor gene polymorphism and type 2 diabetes among bone mineral density. Methods:50 cases of patients with diabetes as the observation group in our hospital, and 50 healthy volunteers as control group, compared two groups of BsmI al elic variation. Results:Vitamin D al ele B and b, the two groups were signiifcant differences were observed in the group gene frequencies were 40%, 60%, in the control group gene frequency of 20%, 80%, observed genotype frequencies 15%, 45%, and 35%in the control group was 10%, 30%and 65%. Al ele with type 2 diabetes are closely linked al ele B can effectively protect type 2 diabetes, al ele b is one of the main type 2 diabetes. Conclusion:Vitamin D receptor gene polymorphism and type 2 diabetes have great bone density associated gene allele b is the main cause of type 2 diabetes.
