CAJ | 학술논문

目的：探讨血浆高敏C反应蛋白（hs-CRP）及B型脑钠肽（NT-proBNP）水平与合并2型糖尿病(T2DM)的急性冠脉综合征（ACS）患者心功能及预后的相关性。方法：82例ACS，分为单纯ACS患者41例，合并T2DM患者41例；血浆hs-CRP、NT-proBNP水平采用酶联免疫吸附法（ELISA）检测，左心室射血分数（LVEF）采用彩色超声多普勒测定,并观察3月、6月的MACE事件。结果：血浆hs-CRP、NT-proBNP水平在合并T2DM的ACS组显著高于无糖尿病(DM)组，而LVEF显著低于单纯ACS组，两组间比较差异有统计学意义（P＜0.05）；血浆hs-CRP、NT-proBNP水平与LVEF呈负相关（P＜0.05）,与3月MACE事件呈正相关。结论：血浆hs-CRP和NT-proBNP水平对于评价合并DM的ACS患者的心功能有一定的意义，可以预测近期预后。
목적：탐토혈장고민C반응단백（hs-CRP）급B형뇌납태（NT-proBNP）수평여합병2형당뇨병(T2DM)적급성관맥종합정（ACS）환자심공능급예후적상관성。방법：82례ACS，분위단순ACS환자41례，합병T2DM환자41례；혈장hs-CRP、NT-proBNP수평채용매련면역흡부법（ELISA）검측，좌심실사혈분수（LVEF）채용채색초성다보륵측정,병관찰3월、6월적MACE사건。결과：혈장hs-CRP、NT-proBNP수평재합병T2DM적ACS조현저고우무당뇨병(DM)조，이LVEF현저저우단순ACS조，량조간비교차이유통계학의의（P＜0.05）；혈장hs-CRP、NT-proBNP수평여LVEF정부상관（P＜0.05）,여3월MACE사건정정상관。결론：혈장hs-CRP화NT-proBNP수평대우평개합병DM적ACS환자적심공능유일정적의의，가이예측근기예후。
[ABSTRACT]Objective: To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) or aminoterminal pro-brain natriuretic peptide (NT-proBNP)and left ventricular ejection fraction (LVEF) in acute coronary syndrome (ACS) patients complicated type 2 diabetes. Methods: Serum levels of hs-CRP,NT-proBNP at baseline were analyzed and LVEF were measured by colored doppler echocardiograph in 41 cases of simple ACS and in 41 cases of ACS complicated type 2 diabetes,and observed the MACE of all patients in 6 month. Results: In the group of ACS complicated type 2 diabetes, LVEF was lower significantly than those in the group of simple ACS,The difference was statistically significant as follows: The analysis showed that hs-CRP or NT-proBNP were related negatively to LVEF (P<0.05) and the MACE of 3 month (P<0.05). Conclusions:The changes of plasma hs-CRP and NT-proBNP are significant in the evaluation of left ventricular function in ACS patients complicated DM,and can predict the prognosis of the near future.