中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2014年
11期
996-999
,共4页
郑丽娥%曲军英%李桑%苏玉红
鄭麗娥%麯軍英%李桑%囌玉紅
정려아%곡군영%리상%소옥홍
人附睾蛋白4%糖类抗原-125%卵巢肿瘤鉴别诊断%病理分型%电化学发光法%免疫组织化学
人附睪蛋白4%糖類抗原-125%卵巢腫瘤鑒彆診斷%病理分型%電化學髮光法%免疫組織化學
인부고단백4%당류항원-125%란소종류감별진단%병리분형%전화학발광법%면역조직화학
human epididymis protein 4%carbohydrate antigen -125%differential diagnosis of the ovary tumor%pathologic typing%electrochemical luminescence method%immunohistochemistry
目的：探讨人附睾蛋白4（ HE4）检测在卵巢肿瘤鉴别诊断及疾病转归中的价值。方法用病例－对照研究方法，分别检测病例组术前以及健康对照组血清人附睾蛋白4和糖类抗原－125（CA125）的水平；用免疫组化方法比较各组的组织上HE4的表达情况，分析HE4分布特点，探讨HE4水平与卵巢癌病理分型的关系以及与肿瘤分期的关系。结果血清HE4水平在56.37 pmol · L－1时，HE4诊断卵巢恶性肿瘤的敏感度为80％，特异度为96％； HE4水平与病理分化呈负相关，而与临床分期呈正相关；HE4在恶性肿瘤组及交界性组表达阳性率明显高于卵巢良性肿瘤组、卵巢非赘生性病变组及其他妇科恶性肿瘤组。血清HE4水平与组织中的HE4表达情况呈正相关。结论 HE4诊断卵巢恶性肿瘤的敏感性和特异性均高于CA125，与CA125联合检测的敏感性最高，血清HE4及组织HE4水平均与卵巢恶性肿瘤病理分型及临床转归均密切关联。
目的：探討人附睪蛋白4（ HE4）檢測在卵巢腫瘤鑒彆診斷及疾病轉歸中的價值。方法用病例－對照研究方法，分彆檢測病例組術前以及健康對照組血清人附睪蛋白4和糖類抗原－125（CA125）的水平；用免疫組化方法比較各組的組織上HE4的錶達情況，分析HE4分佈特點，探討HE4水平與卵巢癌病理分型的關繫以及與腫瘤分期的關繫。結果血清HE4水平在56.37 pmol · L－1時，HE4診斷卵巢噁性腫瘤的敏感度為80％，特異度為96％； HE4水平與病理分化呈負相關，而與臨床分期呈正相關；HE4在噁性腫瘤組及交界性組錶達暘性率明顯高于卵巢良性腫瘤組、卵巢非贅生性病變組及其他婦科噁性腫瘤組。血清HE4水平與組織中的HE4錶達情況呈正相關。結論 HE4診斷卵巢噁性腫瘤的敏感性和特異性均高于CA125，與CA125聯閤檢測的敏感性最高，血清HE4及組織HE4水平均與卵巢噁性腫瘤病理分型及臨床轉歸均密切關聯。
목적：탐토인부고단백4（ HE4）검측재란소종류감별진단급질병전귀중적개치。방법용병례－대조연구방법，분별검측병례조술전이급건강대조조혈청인부고단백4화당류항원－125（CA125）적수평；용면역조화방법비교각조적조직상HE4적표체정황，분석HE4분포특점，탐토HE4수평여란소암병리분형적관계이급여종류분기적관계。결과혈청HE4수평재56.37 pmol · L－1시，HE4진단란소악성종류적민감도위80％，특이도위96％； HE4수평여병리분화정부상관，이여림상분기정정상관；HE4재악성종류조급교계성조표체양성솔명현고우란소량성종류조、란소비췌생성병변조급기타부과악성종류조。혈청HE4수평여조직중적HE4표체정황정정상관。결론 HE4진단란소악성종류적민감성화특이성균고우CA125，여CA125연합검측적민감성최고，혈청HE4급조직HE4수평균여란소악성종류병리분형급림상전귀균밀절관련。
Objective To determine the value of human epididymis pro-tein 4 ( HE4) in the diagnosis and prognosis of ovarian cancer.Methods We use the clinical case -control method, in which the level of HE4 and carbohydrate antigen -125 ( CA125 ) before operation in clinical case and normal women were detected.An immunohistochemistry meth-od was used to measure the expression of HE4 in different tissues.Statis-tical analysis was performed to determine the relationship between the level of HE4, the pathologic type of ovarian cancer, and the stage of the ovarian tumor.Results If the level of HE4 in the serum was 56.37 pmol· L-1 , the sensitivity of HE4 in diagnosing the malignant ovary tumor was 80%and the specificity was 96%.The level of HE4 and the pathological differentiation are negatively related and positively related to the clinical staging .HE4 in the malignant tumor group and borderline tumor group was higher than in other 3 groups, which contained bening ovary tumors, non-neoplastic lesions of ovary and other malignant gyne-cologic tumors.The HE4 level in the serum and HE4 in the tissue were relatively linked.Conclusion HE4 sensitivity and specificity in diagno-sing the ovary malignant tumor is higher than the sensitivity of CA125.The combined detection of HE4 and C125 is more effective.The level of HE4 in serum and HE4 in tissue was respectively closely related to the pathological type and clinical sequelae of the ovary malignant tumor.
