CAJ | 학술논문

目的：评价舌下含服标准化粉尘螨滴剂治疗儿童变应性鼻炎2年疗效及其安全性。方法螨过敏变应性鼻炎儿童240例随机分为观察组和对照组，各120例，对照组氯雷他定或／和康酸莫米松药物治疗，观察组加用舌下含服粉尘螨滴剂，疗程2年，评价治疗前后症状评分和药物评分及安全性。结果2年后，观察组患儿症状评分和药物评分为（3.46±0.85），（0.28±0.43）分，较治疗前的（10.76±1.08），（1.28±0.68）分均明显减少（P均＜0.05），较对照组治疗后的（9.76±1.14），（1.09±0.35）分均明显减少（P均＜0.05）。观察组随访期间出现皮疹、鼻咽痒等11例，对照组出现鼻腔出血，乏力、嗜睡等10例，均未出现过敏性休克等严重全身不良反应。结论舌下含服标准化尘螨滴剂治疗尘螨引起的儿童变应性鼻炎有效，并有较好的安全性。
목적：평개설하함복표준화분진만적제치료인동변응성비염2년료효급기안전성。방법만과민변응성비염인동240례수궤분위관찰조화대조조，각120례，대조조록뢰타정혹／화강산막미송약물치료，관찰조가용설하함복분진만적제，료정2년，평개치료전후증상평분화약물평분급안전성。결과2년후，관찰조환인증상평분화약물평분위（3.46±0.85），（0.28±0.43）분，교치료전적（10.76±1.08），（1.28±0.68）분균명현감소（P균＜0.05），교대조조치료후적（9.76±1.14），（1.09±0.35）분균명현감소（P균＜0.05）。관찰조수방기간출현피진、비인양등11례，대조조출현비강출혈，핍력、기수등10례，균미출현과민성휴극등엄중전신불량반응。결론설하함복표준화진만적제치료진만인기적인동변응성비염유효，병유교호적안전성。
Objective To evaluate the efficacy and safety of sublingual immunotherapy with dermatophagoides farinae standardized extrace for the treatment in children with allergic rhinitis for 2 years.Methods Two hundred and forty children with allergic rhinitis to dermatophagoides ptero-nyssinus( Der P) were randomly allocated to receive either specific immu-notherapy(n=120)or medical treatment(n=120).Symptom and medica-tion scores were assessed to evaluate the clinical efficacy and safety in the baseline and after two year treatment.Results Immunotherapy reduced the symptom [the scores reduced from (10.76 ±1.08) to (3.46 ±0.85)] and medication score [the scores reduced from (1.28 ±0.68) to (0.28 ± 0.43)] in children with allergic rhinitis significantly ( P <0.05), and compared with the control group [ ( 9.76 ±1.14 ) and ( 1.09 ±0.35 ) ] , there was a statistical difference (P<0.05).Eleven local adverse reactions including allergic rash and nasopharyngeal itching occurred observation group, and ten cases of nasal bleeding, fatigue and drowsiness were found in control group, while no fatal systemic reaction occurred in both groups.Conclusion Dermatophagoides farinae standardized extrace for the treat-ment of allergic rhintis is efficacious to treat children sensitive to Der P, al-lergen individualization of dosage is recommended to improve tolerance and security.