CAJ | 학술논문

目的：探讨多烯磷脂酰胆碱与非诺贝特联合治疗非酒精性脂肪性肝炎的临床效果。方法回顾性分析2013年2月~2014年7月我院收治的NAFLD患者114例并按治疗方法分为两组，研究组57例采用多烯磷脂酰胆碱与非诺贝特联合治疗，对照组57例单独应用多烯磷脂酰胆碱治疗。比较两组临床疗效，肝功能及血脂水平。结果研究组总有效率（85.96%）明显高于对照组（64.91%），P＜0.05。研究组和对照组治疗后的ALT、AST、TbiL、GGT与治疗前比较均明显降低（P＜0.05），两组治疗后比较差异无统计学意义（P＞0.05）。研究组和对照组治疗后的TC、TG、LDL-C较治疗前明显降低，而HDL-C则明显升高（P＜0.05），研究组治疗后各指标升高或降低的幅度明显高于对照组（P＜0.05）。结论多烯磷脂酰胆碱与非诺贝特联合治疗非酒精性脂肪性肝炎疗效确切，优于单独应用多烯磷脂酰胆碱治疗，可明显提高临床总有效率，可以在临床推广应用。
목적：탐토다희린지선담감여비낙패특연합치료비주정성지방성간염적림상효과。방법회고성분석2013년2월~2014년7월아원수치적NAFLD환자114례병안치료방법분위량조，연구조57례채용다희린지선담감여비낙패특연합치료，대조조57례단독응용다희린지선담감치료。비교량조림상료효，간공능급혈지수평。결과연구조총유효솔（85.96%）명현고우대조조（64.91%），P＜0.05。연구조화대조조치료후적ALT、AST、TbiL、GGT여치료전비교균명현강저（P＜0.05），량조치료후비교차이무통계학의의（P＞0.05）。연구조화대조조치료후적TC、TG、LDL-C교치료전명현강저，이HDL-C칙명현승고（P＜0.05），연구조치료후각지표승고혹강저적폭도명현고우대조조（P＜0.05）。결론다희린지선담감여비낙패특연합치료비주정성지방성간염료효학절，우우단독응용다희린지선담감치료，가명현제고림상총유효솔，가이재림상추엄응용。
Objective To investigate the effect of combination of polyene phosphatidylcholine combined with fenofibrate for the treatment of nonalcoholic steatohepatitis. Methods A retrospective analysis of 114 patients suffered with NAFLD from Feb 2013 to Jul 2014 in our hospital were divided into two groups , 57 cases of study group accepted polyene phosphatidyl-choline combined with fenofibrate therapy and 57 cases of control group accepted polyene phosphatidylcholine treatment. The clinical efficacy, liver function and blood lipid levels of two groups were compared. Results Compared with the control group (64.91%), the total efficiency of the study group (85.96%) was significantly higher(P<0.05). After treatment, the ALT, AST, TbiL, GGT of study group and control group were significantly lower than prior treatment (P<0.05), there no significant differ-ence after treatment between both groups (P>0.05). TC, TG, LDL-C of study group and control group after treatment decreased significantly than prior treatment, but HDL-C was significantly increased (P<0.05), the increasing or decreasing extent of in-dexes after treatment of study group was higher than control group (P<0.05). Conclusion The polyene phosphatidylcholine combined with fenofibrate for nonalcoholic steatohepatitis has better efficacy than polyene phosphatidylcholine , it can signifi-cantly improve the overall clinical efficiency, it also can be applied in clinic.