CAJ | 학술논문

目的：研究维生素D水平与2型糖尿病微血管并发症的关系。方法159例患者诊断为2型糖尿病，并采用与年龄和性别匹配的对照组。微血管病变检测采用临床评估、尿液检查、眼底检查、神经传导检查以及多种生物化学方法检测，并检测25-羟基胆钙化醇水平，＜20ng/ml定为维生素D缺乏。结果2型糖尿病患者的平均维生素D水平显著降低。与对照组相比，病例组中维生素D缺乏与维生素D不足患者明显增多。维生素D缺乏症与糖尿病微血管并发症神经病变、视网膜病变和肾病存在强相关性。低水平的维生素D与并发两种以上微血管并发症具有强相关性。结论部分糖尿病患者存在维生素D缺乏与不足，可能与糖尿病微血管并发症的发生有关。对糖尿病患者应调整膳食维生素D摄入量、补充适合的维生素D剂量等，或许可以预防或者延缓糖尿病微血管并发症的发生。
목적：연구유생소D수평여2형당뇨병미혈관병발증적관계。방법159례환자진단위2형당뇨병，병채용여년령화성별필배적대조조。미혈관병변검측채용림상평고、뇨액검사、안저검사、신경전도검사이급다충생물화학방법검측，병검측25-간기담개화순수평，＜20ng/ml정위유생소D결핍。결과2형당뇨병환자적평균유생소D수평현저강저。여대조조상비，병례조중유생소D결핍여유생소D불족환자명현증다。유생소D결핍증여당뇨병미혈관병발증신경병변、시망막병변화신병존재강상관성。저수평적유생소D여병발량충이상미혈관병발증구유강상관성。결론부분당뇨병환자존재유생소D결핍여불족，가능여당뇨병미혈관병발증적발생유관。대당뇨병환자응조정선식유생소D섭입량、보충괄합적유생소D제량등，혹허가이예방혹자연완당뇨병미혈관병발증적발생。
Objective To study the correlation of vitamin D levels with microvascular complications in type 2 diabetes. Methods Type 2 diabetics of 159 patients was conducted. Age and sex matched healthy controls were taken. Subjects were e-valuated for the presence of microvascular complications by clinical evaluation, urine examination, fundus examination, nerve conduction studies, and various biochemical tests. 25-OH cholecalciferol levels were done for each. Cut off level for vitamin D deficiency was 20ng/ml. Results Mean vitamin D was lower in type 2 diabetics than healthy subjects. Prevalence of vitamin D deficiency and insufficiency was found to significantly higher in diabetics when compared to healthy subjects. Vitamin D defi-ciency significantly associated with neuropathy, retinopathy, and nephropathy. Lower levels of vitamin D associated with in-creasing prevalence of combinations of microvascular complications namely neuropathy with retinopathy , neuropathy with nephropathy, retinopathy with nephropathy and neuropathy with retinopathy with nephropathy. Conclusion Some patients with diabetes have vitamin D deficiency and inadequate, it may related to the diabetic microvascular complications. The dietary vitamin D intakes should been adjusted and supple with suitable vitamin D dose in diabetes , this may prevent or delay the oc-crurrence of diabetic microvascular complications.