CAJ | 학술논문

目的：系统评价依达拉奉联合亚低温治疗脑梗死的有效性和安全性。方法计算机检索中国生物医学文献数据库（CBM）、中文科技期刊数据库（VIP）、中国期刊全文数据库（CNKI）、万方数字化期刊全文数据库，查找出依达拉奉联合亚低温治疗脑梗死的随机对照试验（RCT），对纳入的RCT进行质量评价，并采用Rev Man 5.2软件进行Meta 分析。结果共纳入17项研究， Meta 分析结果显示，试验组（依达拉奉联合亚低温组）有效率分别与对照组1（常规治疗组， P＜0.00001）、对照组2（依达拉奉组，P=0.0008）比较有显著差异，与对照组3（亚低温组，P＝0.39）无差异；试验组神经功能改善优于对照组1（P＜0.00001）；各组发生不良反应的可能性相当（P＞0.1）。结论依达拉奉联合亚低温治疗脑梗死疗效显著优于常规治疗、单用依达拉奉，与亚低温治疗疗效相当；联合治疗神经功能改善明显优于常规治疗；联合治疗不良反应发生风险并未增加。
목적：계통평개의체랍봉연합아저온치료뇌경사적유효성화안전성。방법계산궤검색중국생물의학문헌수거고（CBM）、중문과기기간수거고（VIP）、중국기간전문수거고（CNKI）、만방수자화기간전문수거고，사조출의체랍봉연합아저온치료뇌경사적수궤대조시험（RCT），대납입적RCT진행질량평개，병채용Rev Man 5.2연건진행Meta 분석。결과공납입17항연구， Meta 분석결과현시，시험조（의체랍봉연합아저온조）유효솔분별여대조조1（상규치료조， P＜0.00001）、대조조2（의체랍봉조，P=0.0008）비교유현저차이，여대조조3（아저온조，P＝0.39）무차이；시험조신경공능개선우우대조조1（P＜0.00001）；각조발생불량반응적가능성상당（P＞0.1）。결론의체랍봉연합아저온치료뇌경사료효현저우우상규치료、단용의체랍봉，여아저온치료료효상당；연합치료신경공능개선명현우우상규치료；연합치료불량반응발생풍험병미증가。
Objective To evaluate the efficacy and safety of Edaravone combined with mild hypothermia intreatment of cerebral infarction. Methods Randomized controlled trials (RCT) were focused on Edaravone and mild hypothermia in the treatment of cerebral infarction were searched from the databases including CBM,VIP,CNKI and Wanfang database. The quality of included RCTs was evaluated by means of Rev Man 5.2 to conduct the Meta-analysis. Results 17 RCTs were included. Meta-analysis results showed that the effectiveness of experimental group (Edaravone and mild hypothermia group) had signifi-cant compared with control group 1(conventional treatment group, P<0.00001) and control group 2(Edaravone group, P=0.0008), and had no significant difference compared with control group 3 (mild hypothermia group, P=0.39). The improvement of neurological function in experimental group had significant difference compared with control group 1 (P<0.00001). The possi-bility of adverse reactions were equal to each group(P>0.1). Conclusion The effectiveness of Edaravone combined with mild hypothermia is better than that of conventional treatment and Edaravone alone , it is equivalent to mild hypothermia alone in treatment of cerebral infarction. However,the combined treatment makes further progress in the improvement of neurological function compared with conventional treatment. Whereas the risk of adverse reactions doesn't increase in the combined treatment.