CAJ | 학술논문

真核细胞内细胞器的酸性环境是内吞作用、溶酶体酶分泌等生理活动的重要条件，液泡三磷酸腺苷酶（ vacuolar ATPases， V-ATP）和氯离子通道（ chloride channel， CLC）家族在真核细胞内各种膜性结构及质膜上广泛分布，它们参与和调节囊泡内的酸化作用，文章对V-ATP酶和CLC蛋白的分布、结构、作用机制及生理病理意义作一综述。
진핵세포내세포기적산성배경시내탄작용、용매체매분비등생리활동적중요조건，액포삼린산선감매（ vacuolar ATPases， V-ATP）화록리자통도（ chloride channel， CLC）가족재진핵세포내각충막성결구급질막상엄범분포，타문삼여화조절낭포내적산화작용，문장대V-ATP매화CLC단백적분포、결구、작용궤제급생리병리의의작일종술。
Acidic environment of organelles of eukaryotic cells plays an important role in endocytosis, the secretion of lysoso-mal enzymes and other physiological activities.V-ATPase (vacuolar ATPases) and CLC (chloride channel) family are widely distribu-ted and present in virtually all eukaryotic cells in intracellular membranes and in the plasma membrane.They are responsible for the a-cidification of the vesicular interior.In this paper, the distribution, structure, mechanism of action and physiological and pathological significance of V-ATPase and CLC protein are discussed.