CAJ | 학술논문

腺苷，作为机体内ATP代谢过程中的重要产物，通过激活腺苷受体（adenosine receptors， AR）（A1R、A2AR、A2BR、A3 R）参与了机体的许多生理及病理过程的调节。腺苷受体在体内的各个组织器官具有广泛的分布，在免疫系统尤为丰富，如中性粒细胞、巨噬细胞、淋巴细胞、树突状细胞均有较高表达。炎症，是机体抵御外来刺激的一种防御性免疫机制，过度的炎症反应则会对机体造成损伤，中性粒细胞是其中重要的参与者之一，腺苷及其受体的调节密切参与了其黏附、迁移、细菌杀伤作用、炎症介质产生、凋亡等过程，从而对炎症起到调节作用。
선감，작위궤체내ATP대사과정중적중요산물，통과격활선감수체（adenosine receptors， AR）（A1R、A2AR、A2BR、A3 R）삼여료궤체적허다생리급병리과정적조절。선감수체재체내적각개조직기관구유엄범적분포，재면역계통우위봉부，여중성립세포、거서세포、림파세포、수돌상세포균유교고표체。염증，시궤체저어외래자격적일충방어성면역궤제，과도적염증반응칙회대궤체조성손상，중성립세포시기중중요적삼여자지일，선감급기수체적조절밀절삼여료기점부、천이、세균살상작용、염증개질산생、조망등과정，종이대염증기도조절작용。
Adenosine, an important metabolic product of ATP, regulates many physiological and pathological processes through activating different adenosine receptors (A1R, A2AR, A2BR, A3R).There is a wide distribution of adenosine receptors in vari-ous tissues and organs particularly in immune system such as neutrophil, which is closely involved in the process of inflammation.In-flammation is defensive immune mechanism body resists external stimulus.The excessive inflammatory reaction will result in injury of the body in which neutrophils are one of the most important participants.The regulation of adenosine and its receptors on neutrophils plays an important role in adhesion, migration, bacterial killing effects, inflammatory mediators release, apoptosis and other processes.