CAJ | 학술논문

目的：亚低温技术对重型颅脑损伤的脑保护作用与预后改善有着广泛的认可。文中分析长期亚低温与短期亚低温治疗对重型颅脑损伤患者预后的影响及并发症的情况。方法按Cochrane系统评价方法，全面检索Cochrane协作网、Pubmed、Embase、CBM、CNKI、万方、维普各数据库对纳入文献的质量进行评估，提取数据后运用RevMan 5．2软件进行Meta分析。结果亚低温治疗长期组相对于短期组改善了预后（格拉斯哥预后评分4～5分）[RR＝1．37，95％CI（1．14，1．64）]，差异有统计学意义（ P＝0．0006）；而在肺炎发生率、心律失常发生率以及应激性溃疡发生率等方向，差异均无统计学意义（ P＞0．05）。结论长期亚低温治疗较短期亚低温治疗对重型颅脑损伤患者的预后有改善作用，没有明显增加肺炎、心律失常、应激性溃疡的发生率。
목적：아저온기술대중형로뇌손상적뇌보호작용여예후개선유착엄범적인가。문중분석장기아저온여단기아저온치료대중형로뇌손상환자예후적영향급병발증적정황。방법안Cochrane계통평개방법，전면검색Cochrane협작망、Pubmed、Embase、CBM、CNKI、만방、유보각수거고대납입문헌적질량진행평고，제취수거후운용RevMan 5．2연건진행Meta분석。결과아저온치료장기조상대우단기조개선료예후（격랍사가예후평분4～5분）[RR＝1．37，95％CI（1．14，1．64）]，차이유통계학의의（ P＝0．0006）；이재폐염발생솔、심률실상발생솔이급응격성궤양발생솔등방향，차이균무통계학의의（ P＞0．05）。결론장기아저온치료교단기아저온치료대중형로뇌손상환자적예후유개선작용，몰유명현증가폐염、심률실상、응격성궤양적발생솔。
Objective Mild hypothermia provides protection for the brain and improves prognosis in the treatment of severe traumatic brain injury, which is widely acknowledged.The article aimed to analysis the prognosis and complications of long-term and short-term mild hypothermia on patients with severe traumatic brain injury. Methods According to the cochrane systematic review methods, thorough search was carried out in databases including Cochrane, Pubmed, Embase, CBM, CNKI, Wanfang and VIP.Eval-uation was made on the quality of selected documents, and Revman5.2 software was applied for meta analysis after data extraction. Results Long-term mild hypothermia achieved improved prognosis compared to short-term mild hypothermia ( GOS score 4 ~5 ) [RR=1.37, 95%CI (1.14, 1.64), P=0.0006].No significant difference was found between these two therapies in pneumonia in-cidence (P=0.94), arrhythmia incidence ( P=0.54) and stress ulcer incidence (P=0.99). Conclusion In comparison to short-term hypothermia therapy, long-term mild hypothermia therapy improved the prognosis of patients with severe traumatic brain inju-ry without obvious increase in the incidence of pneumonia, arrhythmia and stress ulcer.