CAJ | 학술논문

目的：观察安理申对轻中度血管性痴呆的疗效及不良反应。方法60例血管性痴呆患者随机分为对照组和观察组，每组30例，对照组常规给予拜阿司匹林100 mg/d治疗，观察组在常规治疗的基础上加用安理申5 mg/d。分别于服药前、服药4周后和服药12周后应用MMSE评价患者的认知功能、CDR评价患者的痴呆程度、ADL评价患者的日常生活能力，并记录治疗过程中的不良反应。结果服药前，两组患者的MMSE、CDR及BI评分差异均无统计学意义(P>0.05)；治疗3个月后，安理申组患者的各项评分均明显高于对照组(P<0.01)。安理申治疗4周时MMSE分数已有提高(P<0.05)。结论安理申可显著改善轻中度血管性痴呆患者的认知功能、痴呆程度及日常生活能力，且安全性和耐受性良好，是血管性痴呆治疗的有效药物之一。
목적：관찰안리신대경중도혈관성치태적료효급불량반응。방법60례혈관성치태환자수궤분위대조조화관찰조，매조30례，대조조상규급여배아사필림100 mg/d치료，관찰조재상규치료적기출상가용안리신5 mg/d。분별우복약전、복약4주후화복약12주후응용MMSE평개환자적인지공능、CDR평개환자적치태정도、ADL평개환자적일상생활능력，병기록치료과정중적불량반응。결과복약전，량조환자적MMSE、CDR급BI평분차이균무통계학의의(P>0.05)；치료3개월후，안리신조환자적각항평분균명현고우대조조(P<0.01)。안리신치료4주시MMSE분수이유제고(P<0.05)。결론안리신가현저개선경중도혈관성치태환자적인지공능、치태정도급일상생활능력，차안전성화내수성량호，시혈관성치태치료적유효약물지일。
Objective To observe the effect of aricept on patients with mild, moderate vascular dementia. Methods Sixty cases of vascular dementia were randomly divided into the observation group and control group, with 30 cases in each. The control group was given as-pirin 100 mg/d, while the observation group was treated with aricept 5 mg/d on the basis of conventional therapy. The MMSE score, CDR score and ADL score were evaluated respectively before medication and 4, 12 weeks after medication. The side effects were also recorded. Results The score of MMSE, CDR and BI of patients in the two groups were not different before treatment(P>0. 05), while three months after treatment, the score of patients in aricept group was significantly different compared with that of the control(P<0. 01). Four weeks af-ter treatment, the score of MMSE was improved(P<0. 01). Conclusion Aricept can improve the cognitive function, the degree of dementia and ADL of vascular dementia patients, which is one of the efficient ways in the treatment of VD. Moreover, it has high security and good en-durance.