CAJ | 학술논문

目的：研究肽酰基精氨酸脱亚氨酶(PADI4)及其相关的产物瓜氨酸化抗凝血酶(cAT)与胃癌发病的相关性。方法收集胃癌患者和健康者血清，应用酶联免疫吸附测定( ELISA)法检测血清中PADI4蛋白含量及cAT水平。结果和正常对照组相比，胃癌患者血清PADI4蛋白含量及cAT水平显著增高，手术及化疗后PADI4蛋白含量及cAT水平明显降低。结论 PADI4及cAT与胃癌的发病密切相关，对其相关性研究可能为临床胃癌治疗提供新的靶点和策略。
목적：연구태선기정안산탈아안매(PADI4)급기상관적산물과안산화항응혈매(cAT)여위암발병적상관성。방법수집위암환자화건강자혈청，응용매련면역흡부측정( ELISA)법검측혈청중PADI4단백함량급cAT수평。결과화정상대조조상비，위암환자혈청PADI4단백함량급cAT수평현저증고，수술급화료후PADI4단백함량급cAT수평명현강저。결론 PADI4급cAT여위암적발병밀절상관，대기상관성연구가능위림상위암치료제공신적파점화책략。
Objective To study the relationship between peptidylarginine deiminase 4 ( PADI4 ) and citrullinated antithrombin ( cAT) and gastric cancer. Methods Serum of patients and health people was collected. The content of PADI4 and cAT were detected by Enzyme-Linked Immunosorbnent Assay (ELISA). Results The content of PADI4 and cAT was significantly higher in blood of gastric cancer patients than that in samples from health people. The content of PADI4 and cAT was obviously lower after operation and chemothera-py. Conclusion The level of PADI4 and cAT is significantly associated with gastric cancer. The study will provide a new target and strategy for clinical treatment of gastric cancer.