CAJ | 학술논문

目的：探讨地佐辛复合帕瑞昔布钠在小儿扁桃体切除术超前镇痛的作用。方法80例择期行扁桃体切除术患儿,随机分为对照组(C组)、地佐辛组(D组)、帕瑞昔布钠组(P组)、地佐辛复合帕瑞昔布钠组(DP组),每组20例,分别于麻醉诱导前5 min给予生理盐水、地佐辛0.1 mg/kg、帕瑞昔布钠0.8 mg/kg及地佐辛0.1 mg/kg复合帕瑞昔布钠0.8 mg/kg静脉注射。记录术后患儿拔管后0.5、1、2、4、8、12、24h(T1-7)校正面部疼痛评分(FPS-R评分),观察术后不良反应。结果 D组、P组、DP组术后FPS-R评分均低于C组(P<0.01),DP组术后FPS-R评分低于D组、P组(P<0.01),诱导期间C组、P组患儿呛咳多于D组、DP组(P<0.01),C组患儿术后烦躁多于其他各组(P<0.01)。未见其它不良反应。结论地佐辛、帕瑞昔布钠在小儿扁桃体切除术有超前镇痛作用,二者复合应用效果更佳。
목적：탐토지좌신복합파서석포납재소인편도체절제술초전진통적작용。방법80례택기행편도체절제술환인,수궤분위대조조(C조)、지좌신조(D조)、파서석포납조(P조)、지좌신복합파서석포납조(DP조),매조20례,분별우마취유도전5 min급여생리염수、지좌신0.1 mg/kg、파서석포납0.8 mg/kg급지좌신0.1 mg/kg복합파서석포납0.8 mg/kg정맥주사。기록술후환인발관후0.5、1、2、4、8、12、24h(T1-7)교정면부동통평분(FPS-R평분),관찰술후불량반응。결과 D조、P조、DP조술후FPS-R평분균저우C조(P<0.01),DP조술후FPS-R평분저우D조、P조(P<0.01),유도기간C조、P조환인창해다우D조、DP조(P<0.01),C조환인술후번조다우기타각조(P<0.01)。미견기타불량반응。결론지좌신、파서석포납재소인편도체절제술유초전진통작용,이자복합응용효과경가。
Objective To determine the preemptive analgesia of dezocine in combination with parecoxib after tonsillectomy in chil-dren. Methods Eighty children,undergoing selective tonsillectomy were divided into four groups(n=20), control group(C group), dezo-cine group( D group) , parecoxib group ( P group) and dezocine parecoxib group ( DP group) . C group was given normal saline intravenous-ly, D group dezocine 0. 1mg/kg, P group parecoxib 0. 8 mg/kg and DP group ezocine 0. 1mg/kg plus parecoxib 0. 8 mg/kg 5 minutes before induction. The Face Pain Scale-Rvised scales were recorded 0. 5, 1, 2 ,4, 8 ,12, 24 h after extubation. The induction and postoperation complications were recorded. Results The FPS-R scales of D group, P group and DP group were lower than those of C group(P<0. 01). The trend of dysphoria rate was the same as the FPS-R scales(P<0. 01). The FPS-R scales of DP group was lower than D group and P group(P<0. 01). The cough during induction in D and DP group was less than that in the other two groups(P<0. 01). No other complica-tions were seen in the four groups. Conclusion Ezocine and parecoxib have preemptive analgesia after tonsillectomy in children. The pre-emptive analgesia of dezocine in combination with parecoxib is more effective.