CAJ | 학술논문

目的：总结儿童急性鱼胆中毒的临床特征及治疗方式。方法选取2013—2014年泸州医学院附属医院儿科收治的急性鱼胆中毒患儿3例，回顾性分析患儿临床表现、治疗方法、治疗效果及预后。结果患儿均表现为持续剧烈腹痛，以剑突下疼痛为主；伴呕吐，头晕，头痛；实验室检查提示ALT、AST均超出参考范围，伴重度肝功能损害。患儿入院后立即给予血液灌流（ HP）结合内科综合治疗。治疗后，患儿ALT、AST、尿素氮（ BUN）、凝血酶原时间（ PT）出院时均恢复正常，随访未发现肝肾功能异常及深静脉血栓形成等后遗症。结论急性鱼胆中毒可导致患儿重度肝功能损害，尽早行HP结合内科综合治疗是抢救患儿中毒有效的治疗方式。
목적：총결인동급성어담중독적림상특정급치료방식。방법선취2013—2014년로주의학원부속의원인과수치적급성어담중독환인3례，회고성분석환인림상표현、치료방법、치료효과급예후。결과환인균표현위지속극렬복통，이검돌하동통위주；반구토，두훈，두통；실험실검사제시ALT、AST균초출삼고범위，반중도간공능손해。환인입원후립즉급여혈액관류（ HP）결합내과종합치료。치료후，환인ALT、AST、뇨소담（ BUN）、응혈매원시간（ PT）출원시균회복정상，수방미발현간신공능이상급심정맥혈전형성등후유증。결론급성어담중독가도치환인중도간공능손해，진조행HP결합내과종합치료시창구환인중독유효적치료방식。
Objective To analyze the clinical manifestations and its treatment of acute fish bile poisoning in children. Methods The clinical manifestations,laboratory examinations,treatment and results of 3 children with acute fish bile poisoning admitted to the Affiliated Hospital of Luzhou Medical College from 2013 to 2014 were analyzed and relevant literatures reviewed. Results All of the patients had lasting severe abdominal pains,mainly subxiphoid pains,complicated by vomiting,dizziness, headache. By laboratory tests,ALT and AST exceeded the reference range,with severe liver damage. The children were given hemoperfusion(HP)combined with comprehensive medical treatment immediately after admission. The ALT,AST,BUN, prothrombin time were normal at discharge. No hepatorenal dysfunction,deep venous thrombosis or other sequelae occurred in the follow-ups. Conclusion Acute fish bile poisoning can cause severe liver damages in children. Early HP with comprehen-sive medical treatments is an effective therapeutic method.