CAJ | 학술논문

目的：探讨重度子痫前期患者生化指标的变化及其临床意义。方法选择2013年2—12月天津市中心妇产科医院收治的重度子痫前期患者200例，其中早发型100例（早发型组），晚发型100例（晚发型组）。另选择同期本院健康孕妇100例作为对照组。采用全自动生化分析仪检测孕妇生化指标，包括总蛋白（ TP）、清蛋白（ ALB）、前清蛋白（PA）、尿素（Urea）、尿酸（UA）、肌酐（Cr）、胱抑素C（Cys-C）、乳酸脱氢酶（LDH）和羟丁酸脱氢酶（ HBDH）。结果3组生化指标水平比较，差异均有统计学意义（ P<0.05）；其中早发型组和晚发型组TP、ALB、PA水平低于对照组，Urea、UA、Cr、Cys-C、LDH、HBDH水平高于对照组（ P<0.05）；早发型组和晚发型组各生化指标水平比较，差异无统计学意义（ P>0.05）。对照组无不良妊娠发生，早发型组不良妊娠发生率为37%（37/100），晚发型组不良妊娠发生率为13%（13/100）。3组不良妊娠发生率比较，差异有统计学意义（χ2=50.736，P<0.001）。结论重度子痫前期无论是早发型还是晚发型均会引起生化指标水平的改变，且可导致不良妊娠。故及时监测生化指标，对患者进行及时有效的处理，对降低不良妊娠发生率具有重要意义。
목적：탐토중도자간전기환자생화지표적변화급기림상의의。방법선택2013년2—12월천진시중심부산과의원수치적중도자간전기환자200례，기중조발형100례（조발형조），만발형100례（만발형조）。령선택동기본원건강잉부100례작위대조조。채용전자동생화분석의검측잉부생화지표，포괄총단백（ TP）、청단백（ ALB）、전청단백（PA）、뇨소（Urea）、뇨산（UA）、기항（Cr）、광억소C（Cys-C）、유산탈경매（LDH）화간정산탈경매（ HBDH）。결과3조생화지표수평비교，차이균유통계학의의（ P<0.05）；기중조발형조화만발형조TP、ALB、PA수평저우대조조，Urea、UA、Cr、Cys-C、LDH、HBDH수평고우대조조（ P<0.05）；조발형조화만발형조각생화지표수평비교，차이무통계학의의（ P>0.05）。대조조무불량임신발생，조발형조불량임신발생솔위37%（37/100），만발형조불량임신발생솔위13%（13/100）。3조불량임신발생솔비교，차이유통계학의의（χ2=50.736，P<0.001）。결론중도자간전기무론시조발형환시만발형균회인기생화지표수평적개변，차가도치불량임신。고급시감측생화지표，대환자진행급시유효적처리，대강저불량임신발생솔구유중요의의。
Objective To discuss the changes and significance of biochemical indicators in severe preeclampsia pa-tients. Methods 200 severe preeclampsia patients admitted to the Tianjin Central Hospital of Obstetrics and Gynecology from February to December in 2013 were selected,including 100 cases with early onset( early-onset group) and 100 cases with late onset ( late - onset group ) . Another 100 healthy pregnant woman in the same period were selected as the control group. Automatic biochemical analyzer was used to detect TP,ALB,PA,Urea,UA,Cr,Cys-C,LDH and HBDH. Results The biochemical indicators of the three groups showed statistically significant differences(P<0. 05). The TP,ALB and PA in the early-onset group and late-onset group were lower than those of the control group,but the Urea,UA,Cr,Cys-C, LDH and HBDH were higher than the control group(P<0. 05). The biochemical indicators of the early-onset group and late-onset group showed no statistically significant difference(P>0. 05). Control group had no adverse pregnancy,the incidence of adverse pregnancy in early-onset group was 37%(37/100),in late-onset group was 13%(13/100),there was significant difference among 3 groups(χ2 =50. 736,P<0. 001). Conclusion Preeclampsia patients with early or late onset can both cause the changes of biochemical indicators,and cause the adverse outcomes,so timely monitoring of the indicators is of great significance for the early treatment and decreasing the incidence of adverse pregnancy.