医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
36期
42-42
,共1页
肺炎支原体肺炎%肺炎支原体%白介素-8%白介素-10%降钙素原
肺炎支原體肺炎%肺炎支原體%白介素-8%白介素-10%降鈣素原
폐염지원체폐염%폐염지원체%백개소-8%백개소-10%강개소원
Mycoplasma pneumonia(MPP)%Mycoplasma%IL-8%IL-10%PCT
目的探讨血清中白介素-8(IL-8)、白介素-10(IL-10)和降钙素原(PCT)在小儿肺炎支原体肺炎发病中的临床价值。方法用ELISA法和化学发光法检测62例肺炎支原体肺炎患儿治疗前后及50例同期幼儿园和小学生健康体检者血清中IL-8、IL-10和PCT水平,结合临床相关检查资料,对检测结果采用SPSS18.0统计软件进行统计学分析,各组实验数据以均数±标准差(±)表示,各实验组间比较计量资料的t检验,<0.05为有统计学意义。结果 MPP组治疗前:IL-8(16.38±9.63 pg/ml)、IL-10(13.59±8.41 pg/ml)、PCT(0.68±0.52 mg/L)与对照组IL-8(4.66±3.92 pg/ml)、IL-10(5.67±3.03 pg/ml)、PCT(0.29±0.16 mg/L)浓度比较有显著性差异(<0.05);MPP组治疗6~8d后IL-8(5.15±4.49 pg/ml)、IL-10(6.42±5.06 pg/ml)、PCT(0.31±0.18 mg/L)浓度较治疗前均有明显下降,有显著性差异(<0.05),与健康对照组比较,两者差异无统计学意义(>0.05)。结论 MPP患儿入院治疗前、治疗后血清IL-8、IL-l0,PCT含量的变化对疾病的进展和疗效有一定指导意义,提示IL-8、IL-10和PCT在MPP发病机制中起重要作用。
目的探討血清中白介素-8(IL-8)、白介素-10(IL-10)和降鈣素原(PCT)在小兒肺炎支原體肺炎髮病中的臨床價值。方法用ELISA法和化學髮光法檢測62例肺炎支原體肺炎患兒治療前後及50例同期幼兒園和小學生健康體檢者血清中IL-8、IL-10和PCT水平,結閤臨床相關檢查資料,對檢測結果採用SPSS18.0統計軟件進行統計學分析,各組實驗數據以均數±標準差(±)錶示,各實驗組間比較計量資料的t檢驗,<0.05為有統計學意義。結果 MPP組治療前:IL-8(16.38±9.63 pg/ml)、IL-10(13.59±8.41 pg/ml)、PCT(0.68±0.52 mg/L)與對照組IL-8(4.66±3.92 pg/ml)、IL-10(5.67±3.03 pg/ml)、PCT(0.29±0.16 mg/L)濃度比較有顯著性差異(<0.05);MPP組治療6~8d後IL-8(5.15±4.49 pg/ml)、IL-10(6.42±5.06 pg/ml)、PCT(0.31±0.18 mg/L)濃度較治療前均有明顯下降,有顯著性差異(<0.05),與健康對照組比較,兩者差異無統計學意義(>0.05)。結論 MPP患兒入院治療前、治療後血清IL-8、IL-l0,PCT含量的變化對疾病的進展和療效有一定指導意義,提示IL-8、IL-10和PCT在MPP髮病機製中起重要作用。
목적탐토혈청중백개소-8(IL-8)、백개소-10(IL-10)화강개소원(PCT)재소인폐염지원체폐염발병중적림상개치。방법용ELISA법화화학발광법검측62례폐염지원체폐염환인치료전후급50례동기유인완화소학생건강체검자혈청중IL-8、IL-10화PCT수평,결합림상상관검사자료,대검측결과채용SPSS18.0통계연건진행통계학분석,각조실험수거이균수±표준차(±)표시,각실험조간비교계량자료적t검험,<0.05위유통계학의의。결과 MPP조치료전:IL-8(16.38±9.63 pg/ml)、IL-10(13.59±8.41 pg/ml)、PCT(0.68±0.52 mg/L)여대조조IL-8(4.66±3.92 pg/ml)、IL-10(5.67±3.03 pg/ml)、PCT(0.29±0.16 mg/L)농도비교유현저성차이(<0.05);MPP조치료6~8d후IL-8(5.15±4.49 pg/ml)、IL-10(6.42±5.06 pg/ml)、PCT(0.31±0.18 mg/L)농도교치료전균유명현하강,유현저성차이(<0.05),여건강대조조비교,량자차이무통계학의의(>0.05)。결론 MPP환인입원치료전、치료후혈청IL-8、IL-l0,PCT함량적변화대질병적진전화료효유일정지도의의,제시IL-8、IL-10화PCT재MPP발병궤제중기중요작용。
Objective To explore the clinical application of serum IL-8、IL-10 and PCT in children with Mycoplasma Pneumonia(MPP).Methods The levels of serum IL-8、IL-10 and PCT of 62 cases of children with MPP、50 health students as control group were detected by ELISA or chemiluminescence assay at the same time.The clinical relative factors and experimental data were statistical y analyzed using SPSS18.0 statistical software,each set of experimental data expressed as mean±standard deviation,in each experimental group were analyzed by using t-test, <0.05 was considered statistical y significant.Results The levels of serum IL-8、IL-10 and PCT of MPP children(IL-8(16.38±9.63 pg/ml)、IL-10(13.59±8.41 pg/ml)、PCT(0.68±0.52 mg/L) were remarkably higher than those in control group(IL-8(4.66±3.92 pg/ml)、IL-10(5.67±3.03 pg/ml)、PCT(0.29±0.16 mg/L) , <0.01 After 6-8 days treatment,the levels of serum IL-8、IL-10 and PCT of MPP children were remarkably decreased and have no significant dif erence with those in control group.Conclusion The change of serum IL-8、IL-10 and PCT in children with MPP during the treatment indicates that serum IL-8、IL-10 and PCT play an important ef ect in the pathogenesis of MPP.