医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
36期
21-21
,共1页
多囊卵巢综合征%瘦素%脂联素%胰岛素抵抗%肥胖
多囊卵巢綜閤徵%瘦素%脂聯素%胰島素牴抗%肥胖
다낭란소종합정%수소%지련소%이도소저항%비반
Polycystic ovary syndrome%Leptin%Adiponectin%Insulin resistance%Obesity
目的探讨血清瘦素(LEP)和脂联素(APN)与多囊卵巢综合征(PCOS)之间的关系。方法选择2012年8月~2013年8月确诊PCOS的女性39例作为PCOS组。因单纯输卵管因素或/及男方因素不孕就诊的女性42例为非PCOS组。两组再分肥胖组和非肥胖组。检测早卵泡期FSH、LH、T、FPG、FINS、计算HOMA-IR。另测定血清LEP、APN，计算L/A。结果①PCOS组LEP水平及L/A比值显著高于非PCOS组，两组肥胖者均较非肥胖者升高。②PCOS组APN水平显著低于非PCOS组，PCOS组肥胖者较非肥胖者下降。③相关性分析：所有研究对象LEP及L/A比值与HOMA-IR成正相关，APN则与之成负相关。④多元回归分析：单独的LEP或APN指标与PCOS的相关性均不强烈，而L/A比值则与患病有明显相关。结论 LEP、APN可能参与PCOS的发生、发展过程，L/A比值是优于单独的APN或LEP的一个新指标，是PCOS患病的独立危险因素。
目的探討血清瘦素(LEP)和脂聯素(APN)與多囊卵巢綜閤徵(PCOS)之間的關繫。方法選擇2012年8月~2013年8月確診PCOS的女性39例作為PCOS組。因單純輸卵管因素或/及男方因素不孕就診的女性42例為非PCOS組。兩組再分肥胖組和非肥胖組。檢測早卵泡期FSH、LH、T、FPG、FINS、計算HOMA-IR。另測定血清LEP、APN，計算L/A。結果①PCOS組LEP水平及L/A比值顯著高于非PCOS組，兩組肥胖者均較非肥胖者升高。②PCOS組APN水平顯著低于非PCOS組，PCOS組肥胖者較非肥胖者下降。③相關性分析：所有研究對象LEP及L/A比值與HOMA-IR成正相關，APN則與之成負相關。④多元迴歸分析：單獨的LEP或APN指標與PCOS的相關性均不彊烈，而L/A比值則與患病有明顯相關。結論 LEP、APN可能參與PCOS的髮生、髮展過程，L/A比值是優于單獨的APN或LEP的一箇新指標，是PCOS患病的獨立危險因素。
목적탐토혈청수소(LEP)화지련소(APN)여다낭란소종합정(PCOS)지간적관계。방법선택2012년8월~2013년8월학진PCOS적녀성39례작위PCOS조。인단순수란관인소혹/급남방인소불잉취진적녀성42례위비PCOS조。량조재분비반조화비비반조。검측조란포기FSH、LH、T、FPG、FINS、계산HOMA-IR。령측정혈청LEP、APN，계산L/A。결과①PCOS조LEP수평급L/A비치현저고우비PCOS조，량조비반자균교비비반자승고。②PCOS조APN수평현저저우비PCOS조，PCOS조비반자교비비반자하강。③상관성분석：소유연구대상LEP급L/A비치여HOMA-IR성정상관，APN칙여지성부상관。④다원회귀분석：단독적LEP혹APN지표여PCOS적상관성균불강렬，이L/A비치칙여환병유명현상관。결론 LEP、APN가능삼여PCOS적발생、발전과정，L/A비치시우우단독적APN혹LEP적일개신지표，시PCOS환병적독립위험인소。
Objective To investigate the development of PCOS and the influent factors among the LEP,APN.Methods 39 PCOS patients were sampled in experimental group,and 42 patients with pure tubal factor and/or male factor infertility were randomly assigned as control group.Then the two groups were divided into obese and non-obese group.The fol owing outcomes were measured in four groups: ①early fol icular phase serum FSH、LH、T、FPG、FINS;and count HOMA-IR;(2)the serum LEP,APN,and count L/A ratio.Results ①the levels of LEP and the L/A ratios in PCOS patients were higher than that of the non-PCOS patients,the levels of LEP in obese patients were higher than that of non-obese patients. ②the levels of APN in PCOS patients were lower than that of the non-PCOS patients.The levels of APN in obese patients were lower than that of non-obese patients in PCOS patients. ③Cor elation analysis:The level of LEP and L/A ratio was positively correlated with HOMA-IR. ④Multivariate regression analysis:there was no significant cor elation between single LEP or APN and PCOS,but the L/A ratio was significantly related with PCOS.Conclusion LEP,APN may be involved in the occur ence and development of PCOS.The L/A ratio is superior to separate APN or LEP,and it is independent risk factor for the development of PCOS disease.
