CAJ | 학술논문

目的研究急性淋巴细胞白血病(ALL)患者的染色体异常核型及其与临床特征和近期疗效的关系.方法采用骨髓细胞短期培养法、吉姆萨显带对1 10例ALL患者进行染色体核型分析.结果110例ALL患者中,正常核型71例(64.5％),异常核型39例(35.5％),染色体核型结构异常者24例(21.8％),数目异常者11例(10.0％),结构及数目异常者3例(2.7％),异常复杂核型1例.伴有t(9;22) (q34;q11)的ALL患者疗效差于其他患者(确切概率法,P=0.045),伴有t(9；22)(q34;q11)的成年人ALL与儿童ALL疗效差异无统计学意义(确切概率法,P=0.506).结论 ALL患者的染色体核型异常具有随机性,较常见的有t(9；22)(q34；q11)、t(4；11)(q21；q23),其疗效较差.
목적 연구급성림파세포백혈병(ALL)환자적염색체이상핵형급기여림상특정화근기료효적관계.방법 채용골수세포단기배양법、길모살현대대1 10례ALL환자진행염색체핵형분석.결과110례ALL환자중,정상핵형71례(64.5％),이상핵형39례(35.5％),염색체핵형결구이상자24례(21.8％),수목이상자11례(10.0％),결구급수목이상자3례(2.7％),이상복잡핵형1례.반유t(9;22) (q34;q11)적ALL환자료효차우기타환자(학절개솔법,P=0.045),반유t(9；22)(q34;q11)적성년인ALL여인동ALL료효차이무통계학의의(학절개솔법,P=0.506).결론 ALL환자적염색체핵형이상구유수궤성,교상견적유t(9；22)(q34；q11)、t(4；11)(q21；q23),기료효교차.
Objective To investigate the chromosome karyotype of acute lymphocytic leukemia (ALL) and its correlation with the clinical feature and efficacy.Methods The chromosomes of bone marrow/peripheral blood from 110 cases of patients with ALL were prepared after 24 hours culture,and G-banding were used to analyze karyotypes.Results Among 110 patients with ALL,71 cases (64.5 ％) had clonal chromsomal normalities,39 cases (35.5 ％) had clonal chromsomal abnormalities,24 cases (21.8 ％) had chromosome structural abnormalities,11 cases (10.0 ％) had chromosome number abnormalities,3 cases (2.7 ％) had chromosome number and structure abnormalities,one case had chromosomal abnormalities complex karyotype.Efficacy in patients with ALL with t(9;22) (q34;q11) was worse than the other patients (Fisher" s exact text,P =0.045).There was no significant difference on efficacy between in adult ALL associated with t(9;22) (q34;q11) and in children with ALL (Fisher's exact text,P =0.506).Conclusion Chromosome karyotype of ALL patients is random,chromosomal translocations such as t(9;22)(q34;q1 1) and t(4;11) (q21;q23) have poorer treatment outcomes.